Gliclazide (Gliclazide)

Gliclazide MV yog ib tus neeg sawv cev hypoglycemic rau kev kho mob ntshav qab zib hom 2. Cov tshuaj yeeb tshuaj yog Gliclazide.

Tus neeg sawv cev ntawm tus mob ntshav qab zib ntau ntau, yog sulfonylurea derivative ntawm lub cim thib ob. Pab tsim lub cev kom zais cov kua ntshav los ntawm β-hlwb ntawm cov txiav.

Cov tshuaj tsub ntxiv qhov rhiab ntawm peripheral cov ntaub so ntswg rau insulin, txhawb kev ua ub no ntawm intracellular enzymes (tshwj xeeb, leeg glycogen synthetase). Txo lub sijhawm ua ntu zus los ntawm lub sijhawm noj mov kom pib lub insulin secretion. Rov kho lub sijhawm thaum ntxov ntawm insulin secretion, txo qis ncov tom qab ntawm hyperglycemia.

Gliclazide MV txo qis platelet adhesion thiab kev sib sau ua ke, maj mam txo qis kev txhim kho ntawm parietal thrombus, thiab nce vascular fibrinolytic kev ua si. Normalizes vascular permeability.

• Lowers ntshav roj (Cs) thiab Cs-LDL
• Tsub kom lub siab ntawm HDL-C,
• Txo dawb radicals.
• Tiv thaiv kev txhim kho ntawm microthrombosis thiab atherosclerosis.
• Txhim kho microcirculation.
• Txo kom vascular rhiab heev rau adrenaline.

Nrog rau cov ntshav qab zib nephropathy nrog siv ntev, muaj qhov tseem ceeb txo cov proteinuria.

Thaum sau tshuaj rau cov tshuaj, kev tswj hwm glycemic muaj qhov zoo tseem ceeb uas tsis tau txiav txim siab los ntawm cov txiaj ntsig ntawm kev kho nrog antihypertensive tshuaj.

Muaj pes tsawg leeg ntawm Gliclazide MV (1 ntsiav tshuaj):

• Cov tshuaj nquag: gliclazide - 30 lossis 60 mg,
• Cov khoom siv pabcuam: hypromellose - 70 mg, colloidal silicon dioxide - 1 mg, microcrystalline cellulose - 98 mg, magnesium stearate - 1 mg.

Kev ntsuas rau siv

Dab tsi pab Gliclazide MV? Raws li cov lus qhia, ib qho tshuaj rau kev kho mob ntawm kev mob nyhav ntawm hom 2 mob ntshav qab zib mellitus (non-insulin-dependant) nrog kev pib tshwm sim ntawm ntshav qab zib microangiopathy.

Nws tseem ntxiv rau kev tiv thaiv cov mob microcirculatory, ua ib feem ntawm txoj kev kho mob, ib txhij nrog lwm cov sulfonylurea derivatives.

Cov lus qhia siv rau Gliclazide MV (30 60 mg), noj ntau npaum

Cov tshuaj tau noj qhov ncauj 30 feeb ua ntej noj mov.

Qhov pom zoo txhua hnub ntawm Gliclazide MV yog 80 mg pom zoo los ntawm cov lus qhia rau kev siv; yog tias tsim nyog, nws nce mus rau 160-320 mg hauv 2 koob tshuaj.

Dosing ib leeg zuj zus raws li kev yoo mov glycemia thiab 2 teev tom qab noj mov, nrog rau kev kuaj mob ntawm tus kab mob.

Yog tias koj tsis nco qab noj ib zaug, koj tuaj yeem tsis noj ob zaug. Thaum hloov lwm cov tshuaj hypoglycemic, lub sijhawm hloov pauv tsis tas yuav tsum ua - Gliclazide MB pib noj rau hnub tom qab.

Kab tias muaj kev sib txuam nrog biguanides, insulin, alpha-glucosidase inhibitors. Hauv cov mob me mus rau mob raum tsis ua haujlwm, nws yog kws kho mob siv tib co koob tshuaj.

Hauv cov neeg mob uas muaj kev phom sij ntawm hypoglycemia, siv tsawg kawg.

Cov lus qhia tshwj xeeb

Hauv kev kho mob ntawm qhov tsis yog-insulin-mob ntshav qab zib mellitus, cov tshuaj yuav tsum tau siv ib txhij nrog cov zaub mov tsis muaj calorie nrog cov ntsiab lus tsawg ntawm carbohydrates.

Thaum siv tshuaj kho, koj yuav tsum tau soj qab xyuas txhua hnub kev hloov pauv hauv cov piam thaj, nrog rau cov qib ntawm cov piam thaj hauv cov ntshav ntawm lub plab thiab tom qab noj mov tas.

Sab sij huam

Cov kev qhia ceeb toom ceeb toom qhov ua tau ntawm kev txhim kho cov kev mob tshwm sim tom qab thaum sau ntawv Gliclazide MV:

• Xeev siab, ntuav, mob plab,
• Thrombocytopenia, erythropenia, agranulocytosis, hemolytic anemia,
• Ua xua vasculitis,
• Daim tawv nqaij ua pob, khaus,
• Daim siab ua haujlwm
• Pom kev tsis pom kev
• Kev mob ntshav siab (nrog rau kev siv dhau).

Cov Yuav Tsum Muaj

Glyclazide MV yog contraindicated nyob rau hauv cov teeb meem hauv qab no:

• Yam 1 ntshav qab zib mellitus (insulin-dependant),
• Ketoacidosis
• Mob ntshav qab zib precoma thiab coma
• Mob raum thiab mob rau lub siab,
• Kev tsis haum xeeb rau sulfonylureas thiab sulfonamides.
• Kev siv tib lub sijhawm ntawm gliclazide thiab imidazole derivatives (suav nrog miconazole).

Nws yog cov ntawv ceeb toom nrog kev ceev faj rau cov neeg laus, nrog kev noj zaub mov tsis xwm yeem, hypothyroidism, hypopituitarism, mob ntshav siab txaus ntawm cov hlab ntshav thiab cov mob atherosclerosis, adrenal tsis txaus, kev kho mob ntev nrog glucocorticosteroids.

Noj ntau dhau

Cov tsos mob ntau dhau yog pom los ntawm kev mob ntshav qab zib - mob taub hau, nkees, qaug zog loj, tawm hws, palpitations, nce ntshav siab, tsis tuaj yeem, tsaug zog, ntxhov siab, chim siab, chim siab, chim siab, ncua kev tsis pom kev, tsis pom kev thiab hais lus, tshee, kiv taub hau, ua kom qaug dab peg, tsis nco qab.

Nrog cov ntshav qog ntshav nruab nrab uas tsis muaj qhov ua kom tsis nco qab, txo qhov tsawg ntawm cov tshuaj lossis nce tus nqi ntawm cov carbohydrates nrog cov zaub mov.

Yog tias qhov mob ntshav qab zib tsis tsaug zog tau kuaj los yog xav tias tsam tsis haum, 50 ml ntawm 40% kua nplaum tov (dextrose) yuav tsum txhaj (txhaj tshuaj). Tom qab ntawd, ib qho tshuaj 5% dextrose yog txhaj rau qhov tso ntshav, uas tso cai rau koj kom muaj cov ntsiab lus zoo ntawm cov piam thaj hauv cov ntshav (nws yog kwv yees li 1 g / l).

Ntshav qab zib cov ntshav yuav tsum tau saib xyuas kom zoo thiab tus neeg mob yuav tsum tau saib xyuas tsis tu ncua tsawg kawg 2 hnub tom qab pom tseeb tias noj ntau dhau.

Qhov yuav tsum tau soj ntsuam ntxiv ntawm cov haujlwm tseem ceeb ntawm tus neeg mob tau txiav txim siab txuas ntxiv los ntawm nws tus mob.

Txij li thaum cov tshuaj yeeb dej caw feem ntau khi rau cov ntshav plasma protein, kev lim ntshav yog qhov ua tsis tau zoo.

Analogs Glyclazide MV, nqe hauv khw muag tshuaj

Yog tias tsim nyog, koj tuaj yeem hloov Gliclazide MV nrog ib qho analogue hauv kev kho mob - cov no yog cov tshuaj:

Thaum xaiv cov analogues, nws yog ib qho tseem ceeb kom nkag siab tias cov lus qhia rau kev siv Glyclazide MV, tus nqi thiab tshuaj xyuas, tsis txhob siv rau cov tshuaj uas muaj cov nyhuv zoo sib xws. Nws yog ib qho tseem ceeb kom kws kho mob sab laj thiab tsis txhob hloov pauv cov tshuaj ywj siab.

Nqe hauv cov khw muag tshuaj Lavxias: Glyclazide MV 30 mg 60 ntsiav tshuaj - los ntawm 123 txog 198 rubles, Glyclazide MV 60 mg 30 ntsiav tshuaj - los ntawm 151 txog 210 rubles, raws li 471 lub tsev muag tshuaj.

Muab cia rau hauv qhov chaw tsaus, tawm ntawm qhov chaw ncav cuag ntawm cov menyuam ntawm qhov kub txog 25 ° C Txee lub neej yog 3 xyoos.

Kws Tshuaj

Tsub tsub kom insulin ntau ntxiv los ntawm pancreatic beta hlwb thiab txhim kho kev siv ntshav qabzib. Txhawb txoj kev ua ntawm cov leeg glycogen synthetase. Pib hauv metabolic latent mob ntshav qab zib mellitus, nyob rau hauv cov neeg mob nrog exogenously Constitutional kev rog. Normalizes glycemic profile tom qab ob peb hnub ntawm kev kho mob. Nws txo lub sijhawm ua ntu zus los ntawm lub sijhawm noj mov mus rau thaum pib ntawm insulin secretion, rov kho lub sijhawm thaum ntxov ntawm insulin secretion thiab txo qhov hyperglycemia tshwm sim los ntawm kev noj zaub mov. Txhim kho cov ntshav hematological, rheological zog ntawm cov ntshav, hemostasis thiab microcirculation system. Tiv thaiv kev loj hlob ntawm microvasculitis, suav nrog qhov txhab ntawm lub retina ntawm lub qhov muag. Txhawb nqa cov platelet sib sau ua ke, txo qhov sib txawv ntawm qhov txheeb ze rau kev txheeb cais, nce heparin thiab fibrinolytic kev ua haujlwm, nce heparin ua siab ntev. Nws ua kom pom cov khoom ua antioxidant, txhim kho kev sib deev vascularization, muab cov ntshav ntws mus txuas ntxiv hauv microvessels, tshem tawm cov cim ntawm microstasis. Nrog tus mob ntshav qab zib nephropathy, proteinuria tsawg dua.

Hauv kev sim rau kev kawm txog mob ntev ntev thiab hom kev mob toxicity, tsis muaj cov cim qhia ntawm carcinogenicity, mutagenicity thiab teratogenicity (nas, luav), nrog rau cov kev cuam tshuam ntawm kev muaj menyuam (nas) tau tshwm sim.

Siab thiab nrawm nrawm los ntawm lub plab zom mov, C_max ua tiav tom qab 2-6 teev (rau cov ntsiav tshuaj nrog kev tso tawm hloov - tom qab 6-12 teev) tom qab kev tswj hwm. Qhov sib luag ntawm cov ntshav pluaj siab yog tsim tom qab 2 hnub. Kev khi rau cov ntshav plasma nqaij yog 85-99%, qhov ntim ntawm kev faib tawm yog 13 l24 l. Lub sijhawm ncua ntawm kev nqis tes nrog ib koob tau mus txog 24 teev (rau cov ntsiav tshuaj nrog kev tso tawm hloov - ntau dua 24 teev). Hauv lub siab, nws ua rau oxidation, hydroxylation, glucuronidation nrog kev tsim ntawm 8 lub cev tsis ua haujlwm, ib qho muaj cov lus tshaj tawm rau microcirculation. Nws tau tawm hauv cov qauv ntawm cov khoom noj sib xyaw nrog cov zis (65%) thiab los ntawm cov hnyuv (12%). T_1/2 - 8-12 teev (rau cov ntsiav tshuaj nrog kev tso tawm hloov - txog 16 teev).

Phiv los sis tshuaj Glyclazide

Los ntawm cov hnyuv: tsis tshua muaj heev - dyspeptic tsos mob (xeev siab, ntuav, mob plab), tsis tshua muaj tshwm sim - daj ntseg.

Los ntawm cov hlab plawv system thiab ntshav: thim rov qab cytopenia, eosinophilia, anemia.

Ntawm feem ntawm daim tawv nqaij: tsis tshua muaj - muaj tawv nqaij ua xua, tawv tawv.

Los ntawm sab ntawm cov metabolism: ntshav qog.

Los ntawm cov leeg hlwb thiab cov haujlwm hauv lub cev: tsis muaj zog, mob taub hau, kiv taub hau, hloov pauv ntawm qhov saj.

Kev sib txuam

Nyhuv nce ntawm ACE inhibitors, anabolic steroids, beta-blockers, fibrates, biguanides, chloramphenicol, cimetidine, coumarin, fenfluramine, fluoxetine, salicylates, guanethidine, Mao inhibitors, miconazole, fluconazole, pentoxifylline, theophylline, phenylbutazone, phosphamide, tetracyclines.

Barbiturates, chlorpromazine, glucocorticoids, sympathomimetics, glucagon, saluretics, rifampicin, cov thyroid hormones, cov roj ntsha lithium, cov koob tshuaj nicotinic acid ntau, kev tiv thaiv kab mob hauv qhov ncauj thiab tshuaj estrogens - ua kom lub cev tsis muaj ntshav qab zib.

Noj ntau dhau

Cov tsos mob hypoglycemic tej yam kev mob, txog li coma, cerebral edema.

Kev Kho Mob: kev noj cov kua nplaum nyob sab hauv, yog tias tsim nyog - hauv / hauv cov lus qhia ntawm cov kua nplaum tov (50%, 50 ml). Saib xyuas ntshav qabzib, urea nitrogen, ntshiab electrolytes. Nrog rau lub hlwb o nqaij hlav - mannitol (iv), dexamethasone.

Ceev faj Glyclazide

Lub sijhawm xaiv cov koob tshuaj, tshwj xeeb tshaj yog thaum ua ke nrog kev kho tshuaj insulin, nws yog qhov tsim nyog los txiav txim siab qab zib profile thiab kev ua haujlwm ntawm glycemia, yav tom ntej kev saib xyuas tsis tu ncua ntawm cov ntshav qabzib yog qhia. Txog kev tiv thaiv cov mob ntshav qab zib, nws yog ib qho tseem ceeb kom meej meej ib puag ncig ntawm kev ua zaub mov, kom tsis txhob muaj qhov tshaib plab thiab tsis tso dej cawv kiag li. Kev siv cov beta-blockers ib txhij tuaj yeem npog cov tsos mob ntawm kev mob ntshav qab zib. Kev noj zaub mov kom tsawg-carb, tsawg-carb yog pom zoo. Siv nrog ceev faj thaum ua haujlwm rau cov tsav tsheb thiab cov neeg uas muaj kev cuam tshuam los ntawm kev saib xyuas ntau ntxiv.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Gliclazide MV yog tsim nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj nrog hloov kho tso tawm: cylindrical, biconvex, dawb nrog cream zas lossis dawb, me ntsis marbling yog ua tau (10, 20 lossis 30 daim hauv contour aluminium lossis polyvinyl chloride cell pob, 1, 2, 3, 4, 5, 6, 10 pob hauv ib daim ntawv cardboard, 10, 20, 30, 40, 50, 60, lossis 100 pcs. Hauv cov kaus poom yas, 1 tuaj yeem hauv ib daim ntawv cardboard.

Cov muaj pes tsawg leeg ntawm 1 ntsiav tshuaj suav nrog:

• Cov tshuaj nquag: gliclazide - 30 mg,
• Cov khoom siv pabcuam: hypromellose - 70 mg, colloidal silicon dioxide - 1 mg, microcrystalline cellulose - 98 mg, magnesium stearate - 1 mg.

Cov Tshuaj Hauv Tshuaj

Glyclazide yog sulfonylurea derivative uas muaj cov khoom hypoglycemic thiab yog rau cov thawj coj hauv qhov ncauj. Nws qhov sib txawv ntawm cov tshuaj hauv pawg no yog muaj lub nplhaib N-muaj cov heterocyclic uas muaj cov kab mob endocyclic.

Gliclazide txo cov ntshav qabzib, yog ua ib lub zog ntawm insulin ntau lawm los ntawm beta hlwb ntawm islets ntawm Langerhans. Qhov kev nce siab ntawm C-peptide thiab cov tshuaj insulin tom qab muaj sia nyob ntev tom qab 2 xyoos ntawm kev kho mob. Xws li lwm yam sulfonylurea derivatives, cov nyhuv no yog vim muaj cov tshuaj tiv thaiv ntau dhau ntawm β-cov hlwb ntawm cov islets ntawm Langerhans mus rau cov kua nplaum tawm, ua raws li hom physiological. Gliclazide tsis yog cuam tshuam rau cov khoom noj metabolism xwb, tab sis kuj cuam tshuam cov teeb meem hemovascular.

Hauv cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus, gliclazide pab ua kom rov zoo li thaum kawg ntawm insulin ntau lawm, uas yog ib qho txiaj ntsig ntawm cov piam thaj thiab ua rau lub zog thib ob ntawm insulin secretion. Ib qho nce ntxiv hauv insulin synthesis yog txuam nrog cov lus teb rau kev ua kom mob los ntawm cov piam thaj lossis zaub mov noj.

Kev siv cov gliclazide txo txoj kev pheej hmoo ntawm kev txhim kho cov hlab ntsha me me los ntawm kev ua haujlwm rau cov txheej txheem uas tuaj yeem ua rau kev txhim kho ntawm cov kev mob tshwm sim hauv cov neeg mob ntshav qab zib mellitus, txo cov ntsiab lus ntawm platelet ua kom muaj feem (thromboxane)₂, beta-thromboglobulin), ib nrab inhibition ntawm platelet adhesion thiab kev sib sau ua ke, zoo li cuam tshuam rau kev rov kho dua ntawm fibrinolytic yam ntxwv ntawm vascular endothelium, thiab nce kev ua si ntawm plasminogen, uas yog cov ua kom cov nqaij mos.

Kev siv cov hloov kho-tso glycazide, lub hom phiaj glycosylated hemoglobin (HbAlc) lub hom phiaj yog qis dua 6.5%, nrog kev paub zoo glycemic tswj raws li kev soj ntsuam mob txaus ntseeg, tuaj yeem txo kev pheej hmoo ntawm macro- thiab microvascular cov teeb meem sib xyaw nrog hom 2 mob ntshav qab zib piv nrog cov tsoos glycemic tswj.

Kev ua tiav ntawm kev tswj hwm glycemic muaj nyob rau hauv kev sau ntawv ntawm gliclazide (qhov nruab nrab ib hnub yog 103 mg) thiab nce nws cov koob tshuaj (txog li 120 mg ib hnub) thaum noj cov qauv kev kho mob ntawm tus keeb kwm yav dhau (lossis hloov) ua ntej ntxiv nws nrog lwm cov tshuaj hypoglycemic (piv txwv li, insulin, metformin thiazolidinedione derivative, alpha glucosidase inhibitor). Kev siv cov gliclazide hauv pab pawg ntawm cov neeg mob tau txais kev tswj hwm glycemic (qhov nruab nrab, HbAlc tus nqi yog 6.5% thiab lub sijhawm nruab nrab ntawm kev saib xyuas tau yog 4.8 xyoo), piv nrog cov pab pawg ntawm cov neeg mob tau txais kev tswj hwm (qhov nruab nrab HbAlc tus nqi yog 7.3%) ), paub tseeb tias qhov kev pheej hmoo ntawm kev sib koom ua ke ntawm kev sib koom ua ke ntawm cov kab mob micro- thiab macrovascular txo qis ntau yam (los ntawm 10%) vim qhov txo qhov tseem ceeb ntawm tus txheeb ze muaj kev pheej hmoo ntawm kev tsim cov teeb meem loj microvascular (los ntawm 14%), lub sijhawm Itijah thiab kev vam meej ntawm Microalbuminuria (9%), lub raum teeb meem (11%), pib thiab muaj mob ntawm nephropathy (21%), thiab cov kev loj hlob ntawm macroalbuminuria (30%).

Thaum sau tshuaj rau gliclazide, kev tswj hwm glycemic muaj qhov zoo tseem ceeb uas tsis tau txiav txim siab los ntawm cov txiaj ntsig ntawm kev kho nrog antihypertensive tshuaj.

Cov Tshuaj Pharmacokinetics

Tom qab kev tswj hwm ntawm qhov ncauj, glycoside yog nqus hauv cov hnyuv los ntawm 100%. Nws cov ntsiab lus nyob hauv cov ntshav plasma nce zuj zus zuj zus thawj thawj 6 teev, thiab kev mloog zoo nyob ruaj khov li 6-12 teev. Qhov kev txiav txim lossis tus nqi ntawm kev nqus ntawm gliclazide yog ywj pheej ntawm kev noj zaub mov.

Kwv yees li 95% ntawm cov tshuaj nquag khi rau cov ntshav protein. Qhov ntim ntawm kev xa tawm yog li 30 litres. Txais tos ntawm Gliclazide MV hauv kev noj tshuaj ntawm 60 mg ib hnub ib zaug tso cai rau koj los kho cov tshuaj kho gliclazide hauv cov ntshav ntshav rau 24 teev lossis ntau dua.

Gliclazide metabolism tshwm sim feem ntau hauv lub siab. Cov tshuaj pharmacologically nquag metabolites ntawm cov tshuaj no hauv ntshav tsis txiav txim siab. Gliclazide tsuas yog tawm los ntawm lub raum hauv daim ntawv ntawm cov tshuaj nruab nrog cev, kwv yees li 1% yog pom tsis txawv txav hauv cov zis. Qhov nruab nrab ib nrab-lub neej yog 16 teev (qhov ntsuas yuav txawv ntawm 12 txog 20 teev).

Ib txoj kab sib txheeb tau sau tseg ntawm qhov lees qhov tshuaj (tsis pub tshaj 120 mg) thiab thaj chaw hauv qab qhov nkhaus pharmacokinetic "xav txog - sijhawm". Hauv cov neeg laus cov neeg mob, tsis muaj kev hloov pauv hauv lub tsev kho mob.

Cov Yuav Tsum Muaj

• Yam 1 ntshav qab zib mellitus (insulin-dependant),
• Kev mob hnyav rau lub siab thiab lub raum,
• Ketoacidosis
• Mob ntshav qab zib coma thiab precoma
• Siv cov khoom tsis haum nrog imidazole derivatives (suav nrog miconazole),
• Kev tsis haum xeeb rau sulfonamides thiab sulfonylureas.

Kev siv Glyclazide MV tsis raug pom zoo rau kev lactating thiab cov poj niam cev xeeb tub.

Cov lus qhia rau kev siv Gliclazide MV: txoj kev thiab qhov ntau npaum li cas

Gliclazide MV noj rau qhov ncauj ua ntej noj mov.

Qhov txiaj ntsig ntawm kev noj tshuaj yog 2 zaug hauv ib hnub.

Tus kws kho mob txiav txim siab noj ib hnub rau ib leeg zuj zus, raws li cov kev tshawb fawb soj ntsuam ntawm tus kabmob thiab glycemia, ntawm lub plab khoob thiab 2 teev tom qab noj mov.

Raws li txoj cai, thawj koob tshuaj yog 80 mg rau ib hnub, qhov nruab nrab koob yog 160-320 mg rau ib hnub.

Cov lus qhia tshwj xeeb

Hauv kev kho mob ntawm qhov tsis yog-insulin-mob ntshav qab zib mellitus, Gliclazide MV yuav tsum tau siv ib txhij nrog cov zaub mov tsis muaj calorie nrog cov ntsiab lus tsawg ntawm carbohydrates.

Thaum siv tshuaj kho, koj yuav tsum tau soj qab xyuas txhua hnub kev hloov pauv hauv cov piam thaj, nrog rau cov qib ntawm cov piam thaj hauv cov ntshav ntawm lub plab thiab tom qab noj mov tas.

Nrog rau kev phais mob lossis txiav ua kom mob ntshav qab zib mellitus, kev siv tshuaj insulin yuav tsum tau txiav txim siab.

Xws li qhov ua rau lub ntsej muag ntshav qab zib, yog tias tus neeg mob nco qab, qabzib (lossis kua qab zib) yuav tsum siv qhov ncauj. Yog tias tsis nco qab, cov piam thaj (tso ntshav) lossis glucagon (subcutaneously, intramuscularly lossis intravenously) yuav tsum raug tswj hwm. Txhawm rau kom tsis txhob rov txhim kho ntshav qab zib tom qab rov qab nco qab, tus neeg mob yuav tsum tau txais cov zaub mov muaj carbohydrate ntau.

Kev siv ua ke ntawm gliclazide nrog cimetidine tsis pom zoo.

Nrog rau kev siv ua ke ntawm gliclazide nrog verapamil, nws yog ib qho tsim nyog yuav tsum tau saib xyuas qib ntawm cov piam thaj hauv cov ntshav, nrog acarbose, ua tib zoo saib xyuas thiab kho ntawm cov tshuaj ntau dua ntawm cov tshuaj hypoglycemic yog qhov tsim nyog.

Kev cuam tshuam rau kev muaj peev xwm tsav tsheb thiab cov txheej txheem nyuaj

Cov neeg mob noj Glyclazide MV yuav tsum paub txog cov tsos mob tshwm sim ntawm kev mob ntshav qab zib thiab ceeb toom txog qhov yuav tsum tau ceev faj thaum tsav tsheb lossis ua qee yam haujlwm uas yuav tsum muaj kev puas hlwb psychomotor, tshwj xeeb tshaj yog thaum pib kho.

Cev xeeb tub thiab lactation

Tsis muaj kev paub dua nrog kev teem sij hawm ntawm Gliclazide MV rau cov poj niam cev xeeb tub. Cov kev tshawb fawb hauv cov tsiaj tsis tau lees tias muaj teratogenic cov yam ntxwv ntawm tus yam ntxwv ntawm cov tshuaj yeeb dej caw no. Nrog cov nyiaj them tsis txaus rau cov ntshav qab zib mellitus thaum kho, muaj qhov pheej hmoo ntawm kev txhim kho kev mob plab yug me nyuam hauv plab, uas tuaj yeem txo los ntawm kev tswj glycemic txaus. Hloov chaw ntawm gliclazide hauv cov poj niam cev xeeb tub, nws raug nquahu kom siv cov tshuaj insulin, uas tseem yog cov tshuaj uas xaiv rau cov neeg mob npaj lub cev xeeb tub, lossis cov neeg uas tau xeeb tub thaum kho nrog Gliclazide MV.

Txij li thaum tsis muaj cov ntaub ntawv hais txog kev ua kom muaj txiaj ntsig ntawm cov tshuaj muaj txiaj ntsig hauv cov kua mis, thiab hauv cov menyuam yug tshiab muaj qhov pheej hmoo ntawm kev mob neonatal hypoglycemia, noj Gliclazide MB thaum lactation yog contraindicated.

Yeeb tshuaj sib cuam tshuam

Nrog rau kev siv ua ke ntawm Gliclazide MV nrog rau qee yam tshuaj, qhov teebmeem tsis zoo yuav tshwm sim:

• Pyrazolone derivatives, salicylates, phenylbutazone, sulfonamides antibacterial, theophylline, caffeine, monoamine oxidase inhibitors (MAOs): kev muaj zog ntawm cov nyhuv hypoglycemic glyclazide,
• Cov tsis muaj kev xaiv tshuaj beta-blockers: muaj qhov ua rau muaj ntshav qab zib ntau dua, nce tawm hws thiab ntsej muag ntawm tachycardia thiab tshee tshee ntawm tes yam ntxwv ntawm tus mob ntshav qab zib tsawg,
• Gliclazide thiab acarbose: muaj cov nyhuv hypoglycemic,
• Cimetidine: nce plasma gliclazide concentration (mob ntshav qab zib ntau heev yuav tshwm sim, ua rau pom kev poob siab ntawm lub hauv nruab nrab lub paj hlwb thiab lub siab tsis zoo),
• Glucocorticosteroids (nrog rau cov ntawv sab nraud), diuretics, barbiturates, estrogens, progestin, ua ke cov tshuaj estrogen-progestogen, diphenin, rifampicin: txo qis hauv cov nyhuv hypoglycemic glycazide.

Cov lus piv txwv ntawm Gliclazide MV yog: Gliclazide-Akos, Glidiab, Glidiab MV, Glucostabil, Diabeton MV, Diabefarm MV, Diabinax, Diabetalong.

Kev txheeb xyuas ntawm Gliclazide MV

Gliclazide MV belongs rau sulfonylurea derivatives ntawm lub cim thib ob thiab yog tus cwj pwm los ntawm qhov tseem ceeb ntawm qhov kev tiv thaiv hypoglycemic, uas tau piav qhia los ntawm kev sib raug zoo dua rau β-cell receptors (2-5 lub sijhawm siab dua hauv kev tsim ua ntej dhau los ntawm cov tshuaj). Cov khoom no tso cai rau koj kom ua tiav cov kev kho mob nrog cov koob tshuaj tsawg kawg nkaus thiab txo qhov tsawg ntawm cov kev tsis zoo.

Raws li kev txheeb xyuas, MV Gliclazide yog siv rau cov kev mob ntshav qab zib mellitus (retinopathy, nephropathy nrog thawj zaug mob raum tsis ua haujlwm, mob ntsws). Qhov no yog qhia los ntawm cov neeg mob uas tau hloov pauv kom tau txais cov tshuaj no. Qhov no yog vim qhov tseeb tias ib qho ntawm glycazide metabolites cuam tshuam loj heev rau microcirculation, txo qhov mob ntawm angiopathy thiab qhov kev pheej hmoo ntawm kev tsim cov mob microvascular (nephropathy thiab retinopathy). Nyob rau tib lub sijhawm, cov ntshav ntws hauv lub pob txha caj qaum kuj tseem txhim kho thiab vascular stasis ploj.

Ntau tus kws tshaj lij taw qhia tias thaum kho nrog Gliclazide MV, nws yog ib qho tsim nyog kom tsis txhob muaj kev tshaib plab thiab muab kev nyiam rau cov zaub mov muaj txiaj ntsig zoo rau kev noj haus. Txwv tsis pub, tawm tsam tom qab ntawm kev noj zaub mov hauv lub cev tsawg thiab tom qab kev ua kom lub cev ntau dhau, tus neeg mob yuav ua rau lub qog ntshav qab zib. Nrog rau kev ntxhov siab ntawm lub cev, yuav tsum tau txhaj tshuaj kom haum. Hauv qee cov neeg mob, tom qab haus dej cawv thaum kho nrog Gliclazide MV, cov tsos mob ntawm cov ntshav qab zib hauv lub cev kuj tseem tau pom.

Gliclazide MV tsis pom zoo rau kev siv rau cov neeg laus cov neeg mob uas muaj feem ntau yuav ua rau lub qog ntshav qab zib, yog li ntawd, qhov no, nws tsim nyog siv cov tshuaj ua yeeb yam luv luv.

Cov neeg mob nco ntsoov qhov yooj yim ntawm kev siv gliclazide nyob rau hauv daim ntawv ntawm hloov kho cov ntsiav tshuaj: lawv ua qeeb qeeb dua, thiab cov haujlwm tseem ceeb tau faib tusyees thoob plaws lub cev. Vim tias qhov no, cov tshuaj yuav tau noj 1 zaug nyob rau ib hnub, thiab nws txoj kev kho tshuaj yog 2 zaug tsawg dua qhov uas tau ua ntawm gliclazide. Tseem muaj cov ntawv tshaj tawm tias nrog kev kho mob ntev (3-5 xyoos txij li thaum pib tswj hwm), qee cov neeg mob tau txhim kho kev tiv thaiv, uas yuav tsum muaj kev tswj hwm ntawm lwm cov tshuaj muaj suab thaj.

Tsuas tshuaj thiab tswj hwm

Qhov tshwj xeeb ntau npaum li cas ntawm cov tshuaj tau txiav txim siab los ntawm tus kws kho mob koom nrog. Hauv qhov no, tus neeg mob lub hnub nyoog, qhov tshwm sim thiab qhov hnyav ntawm cov tsos mob hauv chaw kuaj mob ntawm tus kab mob, thiab qhov yuav tsum tau yoo mov glycemia qib thiab 2 teev tom qab noj mov tau noj.

Raws li cov lus qhia rau Gliclazide, qhov pib siv thawj hnub yog 80 mg, qhov nruab nrab yog 160 mg, qhov tso cai ntau tshaj yog 320 mg. Cov tshuaj yuav tsum tau noj ib hnub ob zaug 30-60 feeb ua ntej noj mov.

Thawj koob tshuaj ntawm MV Glyclazide yog 30 mg. Yog tias qhov kev kho mob tsis txaus ntseeg ib zaug txhua 2 lub lis piam, ntau npaum li cas txoj kev noj tshuaj tuaj yeem raug maj mam nce mus rau qhov siab tshaj plaws txhua hnub ntawm 120 mg (4 ntsiav tshuaj).