Cov tshuaj los ntawm cov pab pawg statins - kev sib tw ntawm kev sib tw ntawm cov qauv hluav taws xob (statin molecule), cuam tshuam nrog ib feem ntawm cov receptor coenzyme A ncaj qha rau hauv qhov chaw ntawm kev txuas ntawm qhov enzyme no, thiab nws lwm feem nres qhov kev hloov pauv hydroxymethylglutarate hauv mevalonate, uas yog ib nrab ntawm kev sib txuas ntawm ib lub lwg me roj.

Tiv thaiv kev ua ub no CoA muab nyiaj dua txo cov ntsiab lus intracellular roj thiab kev ua kom ntau ntxiv hauv kev ua LDL lub txais, uas ua rau kom nrawm ntawm catabolism roj (Xc) LDLCov. Nws muaj cov lus tshaj tawm-qhov tso tshuaj tiv thaiv hypolipidemic. Cov tshuaj tsis cuam tshuam rau kev ua haujlwm ntawm tus kab mob siab / lipoprotein lipase thiab catabolism ntawm fatty acids.

Akorta muaj cov txiaj ntsig zoo ntawm endothelium ntawm lub cev vascular (ib qho cim ntawm preclinical thaum ntxov) atherosclerosis), normalizes rheological cov yam ntxwv ntawm cov ntshav, muaj antiproliferative thiab antioxidant nyhuv. Qhov siab tshaj plaws ua haujlwm tau manifested 30 hnub tom qab pib siv tshuaj yeeb thiab tseem tshuav tom qab ntawd nyob rau tib theem.

Cov Tshuaj Pharmacokinetics

Cov tshuaj yog zoo nqus los ntawm lub plab zom mov. Kev noj kev haus yuav txo qis kev nqus, bioavailability - kwv yees li 20%. TCmax tau mus txog tom qab - 3-5 teev, dhau ntawm qhov tso cov nyom. Kev mob siab rau cov ntshav protein (90%). Nws tsawv nyob hauv daim siab, qhov twg nws yog metabolized rau N-dimethyl,lactone metabolites. Nws yog tawm hauv lub cev nrog quav nrog quav hauv daim ntawv tsis hloov.

Kev ntsuas rau siv

• Raws li kev noj zaub mov ntxiv rau hypertriglyceridemia thiab lipid-tej kev kho mob,
• Thaum muaj kev sib xyaws hypercholesterolemia lossis thawj hypercholesterolemia, thaum tsis muaj txiaj ntsig, kev sib xyaw nrog kev noj zaub mov nrog lwm txoj kev siv tshuaj uas tsis yog siv tshuaj (kev tawm dag zog lub cev, poob phaus),
• Txhawm rau txhawm rau ua kom qeeb ntawm txoj kev loj hlob atherosclerosis thaum muab tshuaj tua kab mob los tiv thaiv kab mob,
• Txog kev tiv thaiv cov kev mob plawv hauv lub xub ntiag muaj kev pheej hmoo txaus rau kev txhim kho Ischemic mob plawv.

Cov Yuav Tsum Muaj

Lub siab / raum tsis zoo ua haujlwm, siab rhiab heev rau akorta, mob hlwbkev pub mis cev xeeb tubtxais tos cyclosporine, lactase deficiency, hnub nyoog qis dua 18 xyoo.

Siv nrog ceev faj hauv cov neeg mob nrog hypothyroidismntawm kev pheej hmoo ntawm kev loj hlob myopathies, thaum laus, nrog arterial hypotensiontswj tsis tau qaug dab pegcawv abuser nyob rau hauv nrog fibratesnrog kev raug mob ntau heev.

Akorta cov lus qhia rau siv (Txujci thiab ntau npaum li cas)

Cov tshuaj yuav tsum noj tawm tsam ntawm keeb kwm ntawm lipid-txo cov zaub mov noj kom tsawg thiab tus neeg mob yuav tsum tau ua raws nws thoob plaws hauv kev kho mob. Cov koob tshuaj ntawm Akorta raug xaiv raws li lub hom phiaj tsom ntawm lipids thiab nyob ntawm lub hom phiaj kho.

Acorta ntsiav tshuaj raug pom zoo kom noj nyob rau hauv thawj zaug kev noj tshuaj ntawm 10 mg 1 zaug nyob rau ib hnub nrog qhov tseem ntawm nws nce ntxiv tom qab 4 lub lis piam yog tias tsim nyog txog 20 mg. Thaum noj cov tshuaj Acorta, cov lus qhia rau kev siv qhia tias yuav tsum muaj kev saib xyuas cov lipid metabolism thiab qhov xav tau kev hloov tshuaj.

Kev sib txuam

Co-administration ntawm cov tshuaj nrog gemfibrozil nce siab rosuvastatin hauv ntshav 2 zaug. Kev siv Acort meej nrog qhov ncauj tshuaj tiv thaiv ntau ntxiv AUC norgestrel thiab ethinyl estradioluas yuav tsum tau txiav txim siab thaum ua qhov kev hloov kho hormone.

Quag siv cov tshuaj nrog erythromycin nce li ntawm 20% AUC rosuvastatinCov. Noj cov fibrates thiab nicotinic acid hauv kev txhaj tshuaj hypolipidemic tsub ntxiv kev pheej hmoo ntawm myopathiesCov. Txais tos rosuvastatin thiab tshuaj tiv thaiv kab mobuas suav nrog txhuas thiab magnesium hydroxidetxo qhov kev xav zoo rosuvastatin nyob rau hauv cov ntshav los ntawm qhov nruab nrab ntawm 50%. Yog li, nws raug nquahu kom noj tshuaj antacids tsawg kawg 2 teev tom qab noj cov ntsiav tshuaj.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Aorta yog tsim nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj coated nrog zaj duab xis txheej: los ntawm liab dawb mus rau lub teeb liab, puag ncig, biconvex, thaum lub sijhawm so - los ntawm cov tshuaj pleev kom dawb (10 pcs. Hauv cov hlwv, hauv pob ntawv los ntawm 1-3 pob).

Composition 1 ntsiav tshuaj:

• Cov khoom xyaw nquag: rosuvastatin - 10 lossis 20 mg (rosuvastatin calcium - 10.4 lossis 20.8 mg),
• Ntu cov khoom siv (10/20 mg, feem): lactose monohydrate (mis nyuj qab zib) - 89.5 / 179 mg, microcrystalline cellulose - 29.82 / 59.64 mg, calcium hydrogen phosphate (E341) - 10.9 / 21.8 mg , crospovidone - 7.5 / 15 mg, magnesium stearate - 1.88 / 3.76 mg,
• Plhaub (10/20 mg, feem): Opadry II 30K240001 liab dawb (lactose monohydrate (mis nyuj muaj suab thaj) - 2.4 / 4.8 mg, hydroxypropyl methylcellulose (hypromellose) - 1.68 / 3.36 mg, titanium dioxide - 1.413 / 2.826 mg, triacetin (glyceryl triacetate) - 0.48 / 0.96 mg, zas xim liab hlau oxide - 0.027 / 0.054 mg) - 6/12 mg.

Tsuas tshuaj thiab tswj hwm

Acorta ntsiav tshuaj noj ntawm qhov ncauj, tsis hais txog ntawm cov pluas noj, ntxuav nrog dej. Lub sijhawm ntawm hnub ntawm kev noj tshuaj tsis cuam tshuam rau nws qhov txiaj ntsig. Zom thiab zom cov ntsiav tshuaj tsis tas yuav.

Ua ntej kev teem sij hawm ntawm Akorta, tus neeg mob yuav tsum pib ua raws li cov txheej txheem ntawm lipid-txo cov zaub mov noj, uas yuav tsum tau yoog kom mus txog thoob plaws hauv chav kho mob.

Tus kws kho mob xaiv cov koob tshuaj rosuvastatin ua ib leeg zuj zus. Nws yog txiav txim siab los ntawm lub hom phiaj ntawm txoj kev kho thiab kho qhov lus teb, thiab yuav tsum tau ua raws li cov lus pom zoo tam sim no feem ntau rau cov phiaj lipid ntau.

Tshwj tsis yog muaj ntawv tso cai los ntawm kws kho mob, Aorta noj nyob rau hauv thawj koob tshuaj 10 mg 1 zaug nyob rau ib hnub. Thaum txiav txim siab cov koob tshuaj, cov tib neeg cov txiaj ntsig ntawm cov roj (cholesterol) yuav tsum raug coj mus rau hauv tus lej, nrog rau kev muaj peev xwm ntawm kev mob plawv thiab cov kev mob tshwm sim tsis zoo.

Tom qab ib hlis, yog tias tsim nyog, koob tshuaj nce ntawm 2 zaug yog ua tau.

Ib qho kev nce ntxiv ntawm cov koob tshuaj txhua hnub (txog 40 mg) yog qhia rau cov neeg mob uas muaj mob hypercholesterolemia ntau dua thiab muaj kev pheej hmoo siab ntawm cov hlab plawv mob (tshwj xeeb tshaj yog rau cov neeg mob nrog tsev neeg hypercholesterolemia), nyob rau hauv uas xav tau txiaj ntsig ntawm txoj kev kho tsis tau tiav thaum noj qis dua. Cov neeg mob zoo li no yuav tsum muaj kev saib xyuas mob, thiab lawv kuj yuav tsum saib xyuas cov cim raum kev ua haujlwm.

Cov neeg mob uas tsis tau mus ntsib kws kho mob yav dhau los mas tsis pom zoo kom sau tshuaj Akorta ntawm ib koob 40 mg.

Tom qab 2-4 lub lis piam los ntawm kev pib kho, nrog rau kev nce ntxiv, nws yog ib qho tsim nyog los soj qab cov lipid metabolism. Raws li nws cov txiaj ntsig, kev xaiv koob tshuaj yuav raug qhia.

Kev kho ntawm cov koob tshuaj rau cov neeg laus cov neeg mob tsis tas yuav tsum tau ua.

Ib qho kev nce ntxiv hauv cov kab ke ntawm rosuvastatin tau sau tseg ntawm Suav thiab Nyij Pooj, uas yuav tsum tau txiav txim siab thaum tshuaj kho mob.

Kev mob raum tsis ua haujlwm yog qhov tsis muaj tseeb rau kev teem caij Akorta hauv ib koob tshuaj twg, mob pes tsawg - hauv ib koob tshuaj 40 mg txhua hnub.

Rau cov neeg mob uas nqa tshuaj genotypes c.521CC thiab c.421AA, koob tshuaj Akorta txhua hnub yuav tsum tsis txhob siab tshaj 20 mg.

Hauv cov neeg mob uas lub siab tsis ua haujlwm (ntau dua li 9 ntsiab lus ntawm daim ntawv qhia menyuam yaus-Pugh), tsis muaj kev paub dhau los ntawm kev siv tshuaj yeeb. Cov ncauj lus rau kev kho yog kab mob siab hauv theem nquag.

Qhov siab tshaj plaws txhua hnub ntawm 40 mg tsis pom zoo yog tias muaj qee yam uas yuav qhia tau tias tus neeg mob lub siab xav txog kev txhim kho myopathy.

Txoj kev pheej hmoo ntawm myopathy (suav nrog rhabdomyolysis) nce nrog kev nce ntxiv hauv plasma concentration ntawm rosuvastatin, suav nrog vim muaj kev siv tshuaj sib xyaw nrog acorta nrog rau cov tshuaj xws li cyclosporine, qee yam HIV tiv thaiv kab mob tiv thaiv (suav nrog kev siv ritonavir nrog atazanavir, tipranavir thiab / lossis lopinavir). Yog tias ua tau, lwm txoj kev kho yuav tsum raug kho. Yog tias koj xav siv Acorta nrog cov tshuaj no tib lub sijhawm, koj yuav tsum correlate cov txiaj ntsig uas xav pom nrog txoj kev pheej hmoo.

Acorta ntsiav tshuaj 10 thiab 20 mg: cov lus qhia rau kev siv

Acorta yog ib hom tshuaj uas yog muaj tshuaj pharmacological ib pawg hu ua statins. Feem ntau, cov kws kho mob tau sau ntawv rau nws rau cov tib neeg kev txom nyem los ntawm atherosclerosis thiab lwm yam lipid metabolism hauv lub cev. Cov tshuaj no muaj nyob hauv daim ntawv me me ntawm cov yeeb yaj kiab xim-cov ntsiav tshuaj. Cov xim ntawm cov ntsiav tshuaj tej zaum yuav nyob rau hauv txhua qhov ntxoov liab. Lawv yog cov puag ncig ntawm cov duab, convex ntawm ob sab, thiab thaum tawg sab hauv, lawv dawb los yog beige.

Cov khoom siv tseem ceeb ntawm Akorta yog rosuvastatin. Tsis tas li ntawd, ntxiv rau rosuvastatin, cov tshuaj muaj pes tsawg leeg suav nrog xws li cov tshuaj muaj txiaj ntsig xws li lactose, cellulose, calcium, magnesium, crospovidone. Zaj duab xis txheej ntawm cov ntsiav tshuaj nws tus kheej muaj lactose, hypromellose, titanium dioxide, triacetin thiab cov xim zas xim hauv daim ntawv ntawm cov hlau sib txuas. Txhua cov ntsiav tshuaj muaj nyob rau hauv cov pob khoom txheem ntawm 10 daim.

Lub tshuab kev txiav txim ntawm

Akorta, lossis theej, nws lub ntsiab tseem ceeb tshuaj sib xyaw, rosuvastatin, yog qhov tshwj xeeb xaiv tshwj xeeb ntawm ib qho enzyme - hydroxymethylglutaryl-coenzyme A reductase, uas nyob hauv daim ntawv luv luv yuav zoo li HMG-CoA. HMG-CoA yog qhov tseem ceeb heev enzyme uas ua lub luag haujlwm rau kev hloov pauv ntawm hydroxy-3-methylglutaryl-coenzyme A rau cov tshuaj hu ua mevalonate, lossis mevalonic acid.

Mevalonate yog lub sijhawm ua ntej rau cov roj cholesterol, cov roj ntsha ntau dhau ntawm qhov ua rau muaj kev pheej hmoo siab rau atherosclerosis. Kev sib xyaw ua ke ntawm cov roj (cholesterol) thiab tawg ntawm cov roj lipoproteins tsawg (LDL) tshwm sim hauv lub siab. Txij ntawm no nws tuaj yeem hais tau nrog qhov tseeb tias daim siab yog lub hom phiaj tseem ceeb ntawm kev ua yeeb tshuaj.

Cov tshuaj pab ua rau kom ntau ntxiv ntawm cov receptors rau tsawg lipoproteins nyob rau saum npoo ntawm daim siab, vim tias qhov kev cuam tshuam ntawm lawv cov khoom lwj ua kom nce, thiab lipoproteins dawb tsis nkag rau cov ntshav. Ib qho ntxiv, hauv lub siab, lwm pab pawg lipoproteins kuj tseem ua sib txuas - cov leeg tsawg heev (VLDL). Nws yog Akorta uas inhibits lawv cov lus sib txuas thiab ua rau muaj kev txo qis hauv lawv qib hauv tib neeg cov ntshav.

Rosuvastatin pab txo cov roj lipoprotein ntau ntau thiab tsis txaus, thiab tib lub sij hawm nce qib "roj" zoo - los ntawm HDL. Tus nqi ntawm tag nrho cov roj (cholesterol), apolipoproteins B (tab sis, nyeg, tsub kom cov concentration ntawm apolipoproteins A), triglycerides kuj tseem txo qis, theem ntawm "atherogenic" cov roj (cholesterol) yog txo qis.

Qhov txheej txheem ntawm kev ua no piav qhia txog cov txiaj ntsig tseem ceeb ntawm cov tshuaj - lipid-txo qis (cia - txo cov rog). Cov nyhuv no ncaj qha nyob ntawm koob tshuaj uas cov kws kho mob tau cog tseg. Yuav kom ua tiav qhov kev kho mob, uas yog, tus qauv txhawb kev ua haujlwm, nws yog qhov yuav tsum tau noj cov tshuaj rau ib lub lim tiam. Yuav kom tau qhov siab tshaj plaws, "poob siab" qhov tshwm sim, tsawg kawg yog plaub lub lis piam ntawm kev nquag noj thiab kev saib xyuas ntxiv ntawm cov koob tshuaj thiab cov tshuaj noj tshiab.

Daim ntawv thov Akorta mus tau zoo nrog kev teem caij tshuaj los ntawm cov chaw muag tshuaj ntawm cov tshuaj lipid-txo cov tshuaj hu ua fibrates, nrog rau cov nicotinic acid, uas pab ua kom muaj qib siab ntawm lipoproteins ntau.

Daim ntawv noj tshuaj:

Txhua cov ntsiav tshuaj muaj:
cov tshuaj nquag: rosuvastatin calcium - 10.4 mg lossis 20,8 mg (hais txog cov tshuaj anhydrous, uas yog sib npaug nrog cov ntsiab lus ntawm rosuvastatin - 10.0 mg lossis 20.0 mg).
zam txim:
Ntsiav tshuaj tub ntxhais:
rau tshuaj rau 10 mg - lactose monohydrate (mis nyuj muaj suab thaj) 89.50 mg, microcrystalline cellulose 29.82 mg, calcium hydrogen phosphate (E 341) 10.90 mg, crospovidone 7.50 mg, magnesium stearate 1.88 mg,
rau qhov ntau npaum ntawm 20 mg - lactose monohydrate (mis nyuj qab zib) 179.00 mg, microcrystalline cellulose 59.64 mg, calcium hydrogen phosphate (E 341) 21.80 mg, crospovidone 15.00 mg, magnesium stearate 3.76 mg.

Plhaub:
rau qhov tshuaj rau 10 mg - OPADRAY II 30K240001 Paj yeeb (OPADRAY II 30K240001 Paj yeeb) Lactose monohydrate (mis suab thaj) 2.40 mg, hypromellose (hydroxypropyl methylcellulose) 1.68 mg, titanium dioxide 1.413 mg, triacetin (glyceryl triacetate) 0.48 mg, hlau oxide liab oxide 0.027 mg 6.00 mg,
rau qhov ntau npaum ntawm 20 mg - OPADRAY II 30K240001 Paj yeeb (OPADRAY II 30K240001 Paj yeeb) Lactose monohydrate (mis nyuj muaj suab thaj) 4.80 mg, hypromellose (hydroxypropyl methylcellulose) 3.36 mg, titanium dioxide 2.826 mg, triacetin (glyceryl triacetate) 0.96 mg hlau oxide liab oxide 0.054 mg 12.00 mg.

Cov ntsiav tshuaj yog cov yeeb yaj kiab-dhau los ntawm lub teeb liab mus rau xim liab, puag ncig, biconvex. Ntawm so ntawm dawb mus rau xim xim.

Cov lus qhia rau kev siv tshuaj

Aorta yog kho rau ntau yam kev cuam tshuam ntawm lipid metabolism.

Lub ntsiab pov thawj yog qhov muaj ntawm atherosclerosis.

Cov tshuaj yog siv los ntxiv rau hauv cov khoom noj kom txo tau cov roj cholesterol thiab lipoproteins uas tsis muaj qhov hnyav tsawg thiab muaj qhov tsis txaus.

Ntxiv rau qhov no, cov tshuaj tau sau tseg:

• Raws li ib qho ntxiv prophylactic ntawm cov kab mob ntawm cov hlab plawv system nyob rau hauv cov neeg mob tsis muaj kev soj ntsuam kab mob ntawm cov kab mob plawv. Cov no suav nrog myocardial infarction, mob stroke, tawg. Hauv qhov no, lub hnub nyoog ntawm cov neeg mob yog qhov tseem ceeb - rau cov txiv neej nws muaj hnub nyoog laus dua 50 xyoo, thiab rau cov poj niam laus dua 60. Nws tseem tsim nyog xav txog qib qis ntawm lipoprotein cov roj ntshav siab ntau thiab muaj cov kab mob coronary hauv cov txheeb ze tam sim no
• Thawj hypercholesterolemia raws li Fredricksen lossis hom sib xyaw yog qhov nce hauv cov roj (cholesterol) uas tsis muaj mob sab nraud. Cov tshuaj yog kws kho ua ib qho cuab yeej ntxiv, tshwj xeeb yog lwm cov tshuaj, kev noj haus thiab kev siv lub cev tsis txaus kom ua tiav cov txiaj ntsig yam xav tau,
• Qhov hom plaub ntawm hypertriglyceridemia raws li Fredricksen ua ib theem ntxiv hauv kev sib xyaw ua ke nrog kev kho kev noj haus.

Cov tshuaj tiv thaiv kom siv Akorty nyob ntawm seb ntau npaum li cas ntawm cov tshuaj. Rau qhov kev noj tshuaj txhua hnub ntawm 10 txog 20 mg, kev tsis haum tshuaj, mob siab rau lub siab, lossis mob ntev hauv cov mob siab yog contraindications, uas nyob rau hauv kev kuaj ntshav biochemical tau txhais tias yog peb zaug nce siab hauv daim siab ua piv rau cov ntsuas, ib qho kev ua kom tsis zoo rau lub raum tsis ua haujlwm, ib tug neeg lub cev tsis qab rau cov ntshav qab zib. (lactose), nws qhov tsis muaj peev xwm lossis lub cev tsis haum, muaj nyob hauv keeb kwm ntawm myopathy (cov leeg tsis muaj zog), kev sib txuam ntawm cov tshuaj hu ua Cyclospor nyob rau hauv, kev caj ces rau kev txhim kho myopathy, lub sijhawm ntawm cev xeeb tub thiab lactation hauv cov poj niam, hnub nyoog yau.

Thaum muab tshuaj rau Akorta 40 mg ib hnub twg, cov nram qab no contraindications yuav tsum tau ntxiv rau saum toj no contraindications:

1. Cov thyroid tsis txaus - hypothyroidism,
2. Lub xub ntiag nyob hauv tus kheej li keeb kwm lossis hauv qhov txuas ntawm lub zog txuas ntxiv ntawm cov kis mob ntawm cov leeg nqaij,
3. Kev txhim kho ntawm myotoxicity thaum noj tshuaj nrog ib tus zoo ib yam ntawm kev ua,
4. Kev haus cawv ntau dhau,
5. Ib qho xwm txheej twg uas yuav ua rau nce qib hauv rosuvastatin hauv lub cev,
6. Cov neeg mob uas yog haiv neeg Moob
7. Siv ua ke ntawm fibrates,

Tsis tas li ntawd, ib qho kev contraindication yog qhov kuaj pom ntawm tus neeg mob lub cev ntawm kev mob hnyav rau lub raum tsis ua haujlwm.

Acorta Daim Ntawv Tso Tawm

Cov tshuaj muaj nyob hauv daim ntawv foos. Cov duab ntawm cov ntsiav tshuaj yog puag ncig, convex los ntawm 2 sab. yog tias cov ntsiav tshuaj tau tawg rau hauv ib nrab, tom qab ntawd nws cov tub ntxhais yuav yog xim dawb-qab zib.

Lub plhaub ntawm cov tshuaj yog los ntawm lub teeb liab mus rau xim liab tsaus hauv xim thiab xim lub plhaub yog nyob ntawm qhov ntau npaum li cas ntawm cov khoom siv tseem ceeb hauv cov ntsiav tshuaj. Ib qho tshuaj yog muaj nrog kev noj tshuaj ntawm rosuvastatin 10.0, 20.0 thiab 40.0 milligrams.

Acorta ntsiav tshuaj nrog ntau npaum ntawm 10 mg ntawm rosuvastatin:

Ntu cov khoom siv hauv cov ntsiav tshuaj nrog rosuvastatin ntau npaum li 10.0 milligrams:

Cov tshuaj muaj pes tsawg leeg ntawm lub plhaub ntawm cov tshuaj Akorta nrog tshuaj ntawm rosuvastatin 10.0 milligrams:

Pob cov ntsiav tshuaj nrog qhov noj ntau npaum li 10.0 milligram rosuvastatin hauv hlwv ntawm 10 ntsiav tshuaj:

• Cardboard lub thawv nrog cov lus qhia nrog 1 blister (10 pcs),
• Cardboard pob 2 blisters (10 pcs) nrog annotation,
• Cardboard pob nrog cov lus qhia rau siv nrog 3 lub hlwv (10 pcs),

Paj yeeb cov roj (acorta cholesterol) nrog cov koob tshuaj 20.0 milligrams:

Ntu cov khoom siv hauv cov ntsiav tshuaj nrog rosuvastatin ntau npaum 20.0 milligrams:

Cov tshuaj muaj pes tsawg leeg ntawm lub plhaub ntawm cov tshuaj Akorta nrog tshuaj hauv rosuvastatin 20.0 milligrams:

Pob cov ntsiav tshuaj nrog noj tshuaj rosuvastatin 20.0 milligrams hauv hlwv ntawm 10 ntsiav tshuaj:

• Cardboard lub thawv nrog cov lus qhia nrog 1 blister (10 pcs.),
• Cardboard lub thawv 2 lub hlwv (10 pcs.) Nrog annotation,
• Cardboard lub thawv nrog cov lus qhia nrog 3 hlwv (10 pcs.).

Akorta

Kws Tshuaj

Cov tshuaj nquag hauv rosuvastatin muaj cov yam ntxwv los tiv thaiv kev ua haujlwm ntawm cov enzyme HMG-CoA reductase, thiab txo cov khoom mevalonic acid, uas yog qhov ua ntej rau kev sib txuas ntawm cov roj ntsha molecules hauv thawj theem ntawm lawv cov khoom hauv lub hlwb ntawm daim siab (hepatocytes).

Nrog kev pab los ntawm cov tshuaj, Akorta, cov roj uas tsim cov roj cholesterol tau tsawg dua, uas ua rau LDL cov txais, uas, thaum ua haujlwm, pib tua tsiaj rau qis lipoproteins molecular tsawg, ntes lawv thiab thauj lawv rov qab mus rau lub siab ua haujlwm rau kev siv txuas ntxiv siv cov kua tsib.

Ua tsaug rau qhov haujlwm no ntawm cov receptors, lipid catabolism zoo tuaj, muaj qhov txo qhov tseem ceeb hauv cov roj (cholesterol) hauv cov roj.

Tus txheej txheem no pab ntxuav cov ntshav plasma tawm los ntawm cov cholesterol dawb.

Lub ntsiab lus tseem ceeb hauv kev siv tshuaj, rosuvastatin inhibits hepatocytes thiab txo qis lawv cov khoom tsim cov roj ntsha tsis txaus, lub cev ua kom tsis haum ntawm triglycerides.

Cov tshuaj no muaj qhov qhia tau zoo tshaj plaws ntawm lipoproteins, txo lawv cov synthesis los ntawm daim siab ua haujlwm, uas txo qis cov lipoproteins molecular hnyav hauv cov ntshav thiab ua rau kom cov concentration ntawm lipoproteins siab molecular.

Lub ntsiab qhov tseem ceeb ntawm kev raug HMG-CoA reductase los ntawm cov tshuaj Akorta nrog ntau npaum ntawm 10.0 milligrams ntawm rosuvastatin:

• General Performance index ntawm cov roj cholesterol ua kom qis dua 36.0%,
• LDL feem me los ntawm 52.0%,
• Tus lej triglyceride raug txo yog 10.0%,
• Apolipoproteins B txo los ntawm 42.0%,
• Cov kua dej ntawm cov lipoproteins uas ntau-ntau ntau (HDL) tau nce los ntawm 14.0%,
• Apolipoprotein A tau nce ntawm 4.0%.

Cov lus qhia tseeb rau HMG-CoA reductase ntawm cov tshuaj Akorta nrog ib koob tshuaj rosuvastatin 20 mg:

• Zuag qhia tag nrho cov roj Performance index txo ntawm 40.0%,
• Qhov qis qis qis lipid feem (LDL) poob qis los ntawm 55.0%,
• Qhov feem ntawm triglyceride lwg me me txo 23.0%,
• Apolipoproteins B raug txo los ntawm 46.0%,
• Muaj qhov nce ntawm qhov ntau ntawm lipid lwg me me (HDL) los ntawm 8.0%,
• Kev nce hauv apolipoprotein A yog 5.0%.

Cov lipid-txo cov nyhuv ntawm lub cev yog sib npaug rau cov tshuaj muab tshuaj. Kev ua rau txoj kev kho mob kom zoo yog nce mus rau hauv lub sijhawm 7 hnub tom qab pib Acorta.

Tom qab 14 hnub, txoj kev kho mob ua tiav tau tiav los ntawm 90.0%, uas tau lees tias cov tshuaj biochemical tsom ntawm cov muaj pes tsawg leeg ntshav ntshav nrog daim lipid profile.

100.0% ntawm kev kho mob nyhuv yog kuaj tau tom qab noj Acorta ntsiav tshuaj txhua hli. Tom qab ua tiav cov nyhuv thiab txo cov txiaj ntsig ntawm cov feem tsim nyog ntawm cov roj cholesterol, txoj kev kho mob txuas ntxiv rau lwm lub hlis.

Kev nquag ua haujlwm ntawm rosuvastatin tau pom tias muaj txiaj ntsig zoo hauv kev kho mob rau tsev neeg thiab tsis-tsev neeg hypercholesterolemia, nrog kev nce siab ntawm triglycerides lossis tsis muaj qib siab hauv lub cev.

Thiab tseem, Akorta ua tau zoo rau ob hom kabmob ntshav qab zib.

Cov chaw muag tshuaj

Cov Tshuaj Hauv Tshuaj
Rosuvastatin yog ib qho kev xaiv sib tw inhibitor ntawm hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase, ib qho enzyme uas hloov 3-hydroxy-3-methylglutaryl-CoA rau mevalonate, uas yog cov txheej txheem ua ntej ntawm cov roj (cholesterol). Lub hom phiaj tseem ceeb ntawm kev ua ntawm rosuvastatin yog lub siab, qhov twg cov synthesis ntawm cov roj (cov cholesterol) thiab catabolism ntawm lipoproteins tsawg ntom (LDL) yog nqa tawm. Rosuvastatin tsub kom ntau npaum li cas ntawm LDL receptors nyob rau saum npoo ntawm hepatocytes, nce siab zuj zus thiab catabolism ntawm LDL. Nws kuj inhibits cov synthesis ntawm cov qog lipoprotein tsawg heev (VLDL) hauv cov qog hlwb, yog li txo tag nrho cov nyiaj ntawm LDL thiab VLDL.
Rosuvastatin txo qis kev ua haujlwm ntawm LDL cov roj cholesterol, tag nrho cov roj (cholesterol) thiab triglycerides (TG), nce qhov siab ntawm cov roj lipoprotein ntau dua (HDL-C), thiab tseem txo qhov kev kub siab ntawm apolipoprotein B (ApoV), cov roj (cholesterol) uas tsis yog HDL (qhov kev sib xyaw ntawm cov roj cholesterol tag nrho cov theem ntawm cov cholesterol) ), Cov Roj-Cholesterol-VLDL, TG-VLDL thiab nce qhov nce ntawm apolipoprotein A-I (ApoA-I). Rosuvastatin txo qhov sib piv ntawm cov roj-LDL / cov roj (cholesterol)-HDL, cov roj (cholesterol) / cov roj (cholesterol)-HDL, cov roj (cholesterol) uas tsis yog-HDL / cov cholesterol-HDL thiab ApoV / ApoA-Kuv.
Kev lipid-txo cov nyhuv yog ncaj qha ncaj qha rau cov koob tshuaj uas tau xaj tshuaj.
Kev kho kom zoo dua qub hauv 1 lub lis piam tom qab pib kho, tom qab 2 lub lis piam mus txog 90% ntawm qhov ua tau zoo tshaj plaws, cov txiaj ntsig ua kom siab tshaj plaws feem ntau tau ua tiav tom qab 4 lub lis piam thiab tswj nrog kev siv tshuaj ntxiv.
Ua tau zoo rau cov neeg mob cov neeg mob hypercholesterolemia nrog lossis tsis muaj hypertriglyceridemia (tsis hais haiv neeg, poj niam lossis txiv neej), suav nrog hauv cov neeg mob ntshav qab zib mellitus thiab ib daim ntawv muaj keeb ntawm tsev neeg hypercholesterolemia.
Ib qho kev tiv thaiv ntxiv tau pom nyob rau hauv kev sib xyaw nrog fenofibrate (hauv kev sib txuas nrog qhov kev txo qis ntawm cov tshuaj tua kab mob TG) thiab cov nicotinic acid hauv lipid txo cov koob tshuaj (ntau dua 1 g / hnub) (hauv qhov sib piv rau qhov nce ntawm cov kua roj HDL cholesterol).

Cov Tshuaj Pharmacokinetics
Kev Tsis Txaus Siab: meej bioavailability - 20%. Khoom noj khoom haus txo tus nqi ntawm kev nqus. Lub sijhawm kom mus txog qhov siab tshaj plaws (TCmax) yog 3-5 teev tom qab noj. Cais tau los ntawm qhov tsis muaj teeb meem.
Kev xa Khoom: Rosuvastatin yog nqus los ntawm lub siab feem ntau, uas yog lub chaw thaj chaw cov roj (synthesis) thiab cov metabolism hauv LDL-C. Kev faib khoom ntim txog 134 l. Kev sib txuas lus nrog cov ntshav plasma protein (feem ntau nrog albumin) - 90%.
Kev zom zaub mov: 10% ntawm kev noj tshuaj yog metabolized hauv lub siab. Rosuvastatin yog qhov tsis yog-tub ntxhais kawm substrate rau metabolism los ntawm enzymes ntawm cytochrome P450 system. CYP2C9 yog lub ntsiab isoenzyme koom nrog cov metabolism hauv rosuvastatin, thaum isoenzymes CYP2C19, CYP3A4, CYP2D6 tsawg koom nrog nws cov metabolism hauv.
Ntau tshaj li 90% ntawm pharmacological kev ua ub no hauv inhibiting ncig HMG-CoA reductase yog muab los ntawm rosuvastatin, qhov seem yog metabolites. Lub ntsiab metabolites ntawm rosuvastatin yog N-dismethyl thiab lactone metabolites. N-dismethyl yog kwv yees li 50% tsis tshua muaj siab tshaj li rosuvastatin, lactone metabolites yog cov tshuaj pharmacologically tsis voos.
Chaw Sau Ntawv: feem ntau tsuas yog nyob rau hauv daim ntawv tsis hloov pauv (90%) los ntawm txoj hnyuv (suav nrog kev nqus thiab tsis xau rosuvastatin), qhov seem - nrog rau lub raum. Ib nrab-lub neej (T½) yog kwv yees li 19 teev. Ib nrab lub neej tsis hloov nrog qhov nce ntawm koob tshuaj. Qhov ntsuas duab ntawm cov ntshav ntawm lub plasma yog kwv yees li 50 l / h (coefficient ntawm variation 21.7%). Ib yam li lwm qhov HMG-CoA reductase inhibitors, cov kab mob hepatic ntawm rosuvastatin koom nrog cov roj ua kom cov kua roj (thauj cov protein C ntawm cov organic anions), uas ua lub luag haujlwm tseem ceeb hauv hepatic tshem tawm ntawm rosuvastatin.
Kev raug rau lub cev zuj zus ntawm rosuvastatin nce ntxiv hauv kev faib ua feem. Kev hloov pauv ntawm kev siv pharmacokinetic nrog kev siv tshuaj txhua hnub tsis pom.
Poj niam txiv neej thiab lub hnub nyoog tsis muaj kev xav paub pom tseeb hauv lub chaw muag tshuaj ntawm rosuvastatin.
Cov kev tshawb fawb Pharmacokinetic qhia tau nce li thaj tsam li ob zaug ntawm qhov nruab nrab ntawm AUC (thaj chaw hauv qab kev tswj lub sijhawm) thiab Cmax (siab tshaj plaws ntshav plasma) ntawm rosuvastatin hauv cov neeg mob ntawm haiv neeg Asian (Nyiv, Suav, Neeg Philippines, Nyab Laj thiab Kauslim) piv nrog Europeans, Khab. cov neeg mob qhia tau nce ntxiv ntawm nruab nrab AUC thiab Cmax hauv 1, 3 zaug. Pharmacokinetic tsom xam tsis tau qhia tawm qhov sib txawv sib txawv hauv cov chaw muag tshuaj ntawm cov teb chaws Europe thiab cov neeg sawv cev ntawm cov haiv neeg dub.
Hauv cov neeg mob uas mob mentsis mus rau lub raum tsis ua haujlwm, lub plasma ntshav ntawm rosuvastatin lossis N-dysmethyl tsis hloov pauv ntau. Hauv cov neeg mob uas mob raum tsis ua haujlwm (creatinine tshem tawm (CC)) Cov neeg mob uas lub siab tsis ua haujlwm
Tsis muaj kev paub dhau los ntawm kev siv cov tshuaj hauv cov neeg mob uas tau tus qhab nia siab dua 9 ntawm Child-Pugh nplai.
Nrog saib xyuas
Rau cov tshuaj hauv ib hnub ntawm 10 thiab 20 mg: qhov kev pheej hmoo ntawm kev tsim myopathy / rhabdomyolysis - lub raum tsis ua haujlwm, hypothyroidism, tus kheej lossis tsev neeg keeb kwm ntawm cov mob muaj keeb rau cov leeg nqaij thiab cov keeb kwm yav dhau los ntawm cov leeg mob nrog lwm HMG-CoA reductase inhibitors lossis fibrates, kev haus cawv ntau dhau, tej yam kev mob uas muaj ntau ntxiv nyob rau hauv lub plasma concentration ntawm rosuvastatin, hnub nyoog tshaj 65 xyoo, keeb kwm ntawm kab mob siab, mob sepsis, hlab ntaws ntshav hypotension, kev phais mob dav Twa, kev poob plig, mob metabolic, endocrine los yog ntsha mob, uncontrolled, qaug dabpeg, haiv neeg (Mongoloid haiv neeg), concomitant siv fibrates.
Kev noj tshuaj rau txhua hnub ntawm 40 mg: mob raum tsis ua haujlwm (CC ntau dua 60 ml / min), hnub nyoog tshaj 65 xyoo, keeb kwm ntawm daim siab mob, sepsis, mob ntshav siab, kev phais mob ntau, kev ceeb, mob ntshav qab zib, endocrine lossis electrolyte cuam tshuam lossis kev chua leeg.

Kev qhia rau kev teem caij siv tshuaj Akorta

Cov tshuaj Rosuvastatin Canon tau sau tseg rau kev kho mob ntawm cov kab mob xws li nce cov roj (cholesterol) hauv cov ntshav plasma:

• Thawj lub tsev kho mob tsis yog hom kab mob muaj keeb (hyperterterolemia) (hom 2A raws li Fredrickson),
• Thawj hypercholesterolemia tsis yog tsev neeg etiology,
• Sib xyaw hom hyperlipidemia (2B hom raws li Fredrickson), cov nquag ua haujlwm ntawm rosuvastatin ua cov lus txuas rau cov khoom noj muaj roj cholesterol,
• Pathology ntawm dysbetalipoproteinemia (hom 3 raws li Fredrickson),
• Tsev neeg etiology ntawm hypertriglyceridemia (Fredrickson hom 4),
• Nrog homozygous hom mob muaj keeb hypercholesterolemia, nws yog siv nrog kev noj zaub mov noj los yog nrog lwm cov tshuaj noj cov cholesterol. Lossis yog cov roj (cholesterol) noj hauv lub cev tsis ua haujlwm,
• Yuav kom nres qhov kev mob zuj zus ntawm cov kab mob sclerosis, kuj suav nrog kev noj haus.

Thawj qhov kev tiv thaiv ntawm cov pathologies:

• Myocardial infarction
• Cerebral mob hlab ntsha tawg paj hlwb tawg paj hlwb lossis hlab hlwb txhaws,
• Lub plawv hloov ischemia,
• Nrog kev hloov kho mob,
• Tom qab 50 xyoo hauv cov txiv neej thiab 60 xyoo hauv poj niam,
• Txhawm rau kom txo C-reactive protein tebchaw,
• Cov neeg mob uas muaj qaug tshuaj qaug cawv thiab qaug cawv,
• Nrog kev txhim kho tawg,
• Kev tiv thaiv ntawm tsis ruaj tsis khov angina pectoris, as Well as arrhythmias.

Qhia tom qab mob stroke

Sab sij huam

Cov kev mob tshwm sim ntawm lub cev raug faib los ntawm kev ntsuas zaus hauv kev soj ntsuam:

• Txaus lossis ntau zaus, qhov no ntau dua 1 rooj plaub ntawm 10 tus neeg mob,
• Feem ntau qhov no yog 1 kis rau 100 tus neeg mob,
• Tsis yog feem ntau qhov no yog 1 kis rau 1000 tus neeg mob,
• Tsis tshua muaj 1 rooj neeg txog 10,000 tus neeg mob,
• Cov xwm txheej tsis tshua muaj lossis raug cais 1 kis ntawm ntau tshaj 10,000 tus neeg mob noj tshuaj Acorta:

Tachycardia yog ib qho kev phiv los ntawm kev noj tshuaj.

Acorta Ntau Npaum Li Cas thiab Cov Tswv Yim Tswj Xyuas

Cov kev cai rau kev noj tshuaj rau qhov ntsuas siab ntawm cov roj (cholesterol) Akorta:

• Pib kev pib siv tshuaj kho nrog Akorta tshuaj pib nrog hypocholesterol noj mov,
• Tag nrho cov chav kawm ntawm kev kho mob nrog Acorta tseem nrog kev noj haus,
• Qhov ntau npaum no yog xaiv los ntawm tus kws kho mob ib leeg zuj zus thiab raws li qhov ntsuas ntawm lipogram,
• Koj yuav tsum haus cov ntsiav tshuaj tag nrho thiab tsis txhob zom, thiab haus dej kom ntau,
• Thawj koob tshuaj Acorta yog 10.0 milligrams, ib hnub ib zaug, tsis khi rau cov txheej txheem ntawm kev noj zaub mov,
• Nce qhov ntau npaum li cas lossis hloov cov tshuaj, tsuas yog tus kws kho mob tuaj koom tuaj yeem ua qhov txhab, tab sis tsis ntxov dua tom qab ib hlis ntawm kev kho mob,
• Kev siv ntau tshaj plaws hauv ib hnub yog 40.0 milligrams, raug kho tsuas yog hauv tsev kho mob hauv qab kev saib xyuas tas li ntawm cov txheej txheem kho mob los ntawm tus kws kho mob,
• Qhov ntau ntau tau muab tshuaj tsuas yog rau cov neeg mob uas muaj kev mob hnyav ntawm kev muaj kab mob atherosclerosis,
• Nrog rau kev kho nrog qhov ntau npaum li 20.0 milligrams, saib xyuas tus roj cholesterol 2 zaug hauv ib hlis,
• Ntxiv thiab, nyob rau qhov siab tshaj plaws nyob rau hauv ib hnub, kuaj xyuas tas li ntawm creatine phosphokinase index,
• Cov neeg mob laus tsis tas yuav ib qhov kho kom haum.

Qhov siab dua ntau dua ntawm cov tshuaj nquag hauv cov ntsiav tshuaj, ntau qhov cuam tshuam tsis zoo rau lub cev los ntawm nws txoj kev tswj hwm. Akort ntau npaum ntawm 40.0 milligrams ua rau muaj kev phiv ntau tshaj plaws, yog li koj yuav tsum pib kho nrog kev noj tshuaj qis.

Rau cov neeg mob uas muaj qhov pheej hmoo loj ntawm kev mob plawv, lossis pathologies ntawm cov ntshav ncig, tus kws kho mob tuaj yeem sau tshuaj rau qhov siab ntawm 40.0 milligrams, tab sis tsuas yog tias cov tshuaj Akorta lossis nws cov tshuaj ntxiv nrog rau kev noj tshuaj hauv qab tsis coj cov tshuaj tshwm sim los txo cov roj cholesterol Cov.

Kev nce ntxiv ntawm lub zog ntawm cov tshuaj tuaj yeem nqa tawm tsuas yog tom qab kuaj pom los ntawm lipid spectrum txuj ci.

Raws li kev kuaj mob kev ntsuam xyuas, tus kws kho mob txiav txim siab txog qhov yuav tsum tau nce cov tshuaj ntau npaum li cas.

Qhov ntau dua qhov ntau npaum ntawm cov tshuaj nquag hauv cov ntsiav tshuaj, qhov cuam tshuam ntau dua tsis zoo rau lub cev los ntawm kev noj nws

Kev siv cov tshuaj Akort thaum cev xeeb tub

Cov tshuaj Akorta tsis yog cov kws kho rau cov pojniam thaum lub sijhawm yug menyuam, nrog rau lub sijhawm pub mis.

Cov poj niam ntawm kev ua me nyuam thaum muaj hnub nyoog thaum lub sij hawm ntawm txoj kev kho nrog tshuaj ntawm cov pab pawg statin yuav tsum saib xyuas kev tiv thaiv lawv lub cev los ntawm qhov tsis pom qhov txheej txheem ntawm menyuam.

Yog tias tus poj niam pom tau muaj tus poj niam cev xeeb tub thaum lub sijhawm noj tshuaj Akorta, tom qab ntawd koj yuav tsum cuam tshuam cov tshuaj tam sim ntawd thiab kuaj tus niam thiab tus me nyuam hauv plab.

Cov lus qhia tshwj xeeb rau kev teem caij

Thaum sau tshuaj rau ib qho tshuaj 40.0 mg rau cov neeg mob, kev tshuaj xyuas tas li ntawm txhua lub raum yog tsim nyog. Yog hais tias kev kuaj pom pom 5 zaug ntawm qhov ntsuas ntawm creatine phosphokinase, tom qab 4 rau 5 hnub, koj yuav tsum rov kuaj dua.

Yog tias rov qab kuaj pom tau pom tib yam tshwm sim nrog cov lus qhia thawj zaug, tom qab ntawv kho nrog kev siv 40.0 milligrams ntawm Acorta yuav tsum tsis txhob pib.

Nws kuj yog qhov yuav tsum tau thim kev kho mob nrog Acorta rau cov leeg pathologies, yog tias creatine phosphokinase kuj nce 5 los yog ntau dua.

Thaum qhov mob feem ntau tau txum tim rov qab thiab cov leeg mob txo qis, kev kho mob tuaj yeem rov ua dua, tab sis nrog cov tshuaj ntawm Acorta tsis siab tshaj 20.0 milligrams. Concurrent immunosuppressant kev kho mob kuj tseem xav tau.

Nrog rau qhov kev nce ntxiv hauv cov tshuaj thaum lub sijhawm kho nrog Akorta rau qhov siab tshaj plaws, saib xyuas cov teeb meem lipid siv cov tshuaj biochemistry nrog cov lipid profile, ntxiv rau daim siab hloov pauv hauv lub siab.

Yog tias tus neeg mob muaj cov ntshav qabzib ntau dua 6.0 mmol ib litre, ces kev kho mob nrog Acorta tuaj yeem ua rau txhim kho hom ntshav qab zib zaum ob.

Thaum kho, koj yuav tsum tau saib xyuas cov piam thaj hauv cov ntshav tas li.

Akorta cov tshuaj noj yog muab rau cov neeg thib plaub xyoo statins nrog cov khoom xyaw ua si rosuvastatin, thiab muaj ntau yam duab analogues ntawm Lavxias thiab txawv teb chaws ntau lawm:

Tus nqi ntawm cov tshuaj ntawm Akort thiab nws cov analogues

Xaus

Kev siv tshuaj noj Lavxias los txo qis ntshav cov ntshav yuav dhau los tsuas yog cov kws kho mob koom nrog, qhov kev noj tshuaj tau tsim los ntawm nws, thiab cov koob tshuaj yuav tsum tsis txhob hloov pauv ntawm nws tus kheej. Cov chav kawm txog yeeb tshuaj yog nrog cov khoom noj kom yuag hauv lub cev xav tau.

Txoj kev kho yog kwv nrog kev soj ntsuam tas mus li ntawm cov kws kho mob koom thiab ntsuas qhov ntsuas cov roj ua ntej.

Sergey, 54 xyoo: 3 xyoos dhau los Kuv tau kuaj mob atherosclerosis ntawm ob txhais ceg. Qhov kev noj haus tsis ua rau kuv cov roj cholesterol tsawg, thiab tus kws kho mob tau hais rau kuv tias yog statins. Kuv coj Krestor tau rau lub hlis, tab sis haus cov tshuaj tsis tu ncua yog qhov kim heev.

Nws hais kom tus kws kho mob hloov nws nrog lwm cov statins, thiab nws tau muab tshuaj rau kuv ntawm Akort. Kuv txaus siab rau qhov tshwm sim, thiab rau tus nqi tshuaj Lavxias haum rau kuv.

Kuv tsis muaj kev phiv dab tsi rau lub cev, tsuas yog thaum pib tsis muaj xeev siab heev.

Galina, 59 xyoo: tom qab pib mob lawm, kuv cov roj (cholesterol) nce ntxiv, thiab kuv pib yuag nce phaus ntau heev.

Tom qab ua kom tsis txhob mob hypocholesterol, Kuv tswj kom yuag qee qhov hnyav, tab sis kuv cov roj (cholesterol) tsis tau poob ntau. Tus kws kho mob tau sau tshuaj rau kuv Akorta cov tshuaj.

Tom qab 2 lub hlis ntawm kev kho mob, cov roj cholesterol rov qab mus rau qhov qub, tab sis kuv noj zaub mov.

Siv thaum cev xeeb tub thiab thaum pub niam mis

Cov tshuaj Akorta yog contraindicated rau kev siv thaum cev xeeb tub thiab thaum pub niam mis. Cov poj niam ntawm kev muaj me nyuam hnub nyoog yuav tsum siv txoj kev pom zoo thiab tsim nyog ntawm kev tswj kom tsis muaj menyuam. Txij li cov roj (cholesterol) thiab cov roj (cholesterol) biosynthesis tseem ceeb yog qhov tseem ceeb rau kev loj hlob ntawm menyuam, qhov kev pheej hmoo ntawm kev ua kom tsis txhob noj HMG-CoA reductase ntau tshaj cov txiaj ntsig ntawm kev siv tshuaj hauv cov pojniam cev xeeb tub. Yog tias cev xeeb tub thaum kho, cov tshuaj yuav tsum nres tam sim ntawd. Tsis muaj ntaub ntawv hais txog kev faib cov rosuvastatin nrog rau niam cov kua mis, yog li ntawd, thaum lub sijhawm pub niam mis, cov tshuaj yuav tsum tau tsum tsis ua ntxiv.

Tsuas tshuaj thiab tswj hwm

Ua ntej pib siv tshuaj nrog cov tshuaj, tus neeg mob yuav tsum pib ua raws li kev noj qab haus huv lipid-txo cov zaub mov thiab txuas ntxiv ua raws nws thaum kho. Cov koob tshuaj ntawm cov tshuaj yuav tsum tau xaiv ib tus zuj zus nyob ntawm lub hom phiaj ntawm txoj kev kho thiab kho cov lus teb, suav txog qhov tam sim no feem ntau lees txais cov lus pom zoo rau cov hom phiaj lipid.
Cov tshuaj Akorta noj ntawm qhov ncauj, txhua lub sijhawm ntawm ib hnub, tsis hais noj zaub mov, tsis ntxo lossis zom cov ntsiav tshuaj, nqos tag nrho, haus nrog dej.
Qhov pom zoo kom pib koob tshuaj (tshwj tsis yog muaj lwm yam tshwj xeeb) yog 10 mg ib hnub ib zaug rau cov neeg mob uas tsis tau noj dua yav dhau los HMG-CoA reductase inhibitors, thiab rau cov neeg mob hloov mus rau cov tshuaj no tom qab kho nrog lwm HMG-CoA reductase inhibitors.
Yog tias tsim nyog, cov koob tshuaj yuav tau nce ntxiv tom qab 4 lub lis piam txog 20 mg.
Vim tias qhov tshwm sim muaj feem ntawm cov kev mob tshwm sim thaum noj ntau dua 40 mg, piv nrog cov koob tshuaj qis dua, nce qhov koob tshuaj rau 40 mg tuaj yeem nqa tawm tsuas yog nyob rau hauv cov neeg mob uas muaj mob hypercholesterolemia thiab muaj kev pheej hmoo siab ntawm cov hlab plawv mob (tshwj xeeb tshaj yog nyob rau cov neeg mob uas muaj tsev neeg hypercholesterolemia ), nyob rau hauv uas xav tau txiaj ntsig ntawm txoj kev kho tsis tau ua tiav thaum noj ib koob tshuaj 20 mg, thiab uas yuav nyob hauv kev saib xyuas kev kho mob.
Pom zoo tshwj xeeb kev saib xyuas ntawm cov neeg mob tau txais cov tshuaj hauv ib koob tshuaj 40 mg yog pom zoo. Kev noj tshuaj ntawm 40 mg tsis pom zoo rau cov neeg mob uas tsis tau mus ntsib kws kho mob dhau los. Tom qab 2-4 lub lis piam ntawm kev kho mob thiab / lossis nrog kev nce ntxiv ntawm cov tshuaj, yuav tsum saib xyuas cov lipid metabolism yog qhov tsim nyog (yog tias tsim nyog, yuav tsum tau kho tshuaj).
Hauv cov neeg mob noj cov tshuaj ntawm ib koob ntawm 40 mg, nws raug nquahu kom soj ntsuam lub raum kev ua haujlwm.
Thaum tau sau ntawv noj nrog gemfibrozil, koob tshuaj ntawm rosuvastatin yuav tsum tsis pub tshaj 10 mg / hnub.
Cov neeg laus yog cov tsis xav tau kev hloov kho koob.
Thaum kawm cov tshuaj pharmacokinetic nyob rau hauv cov neeg mob sib txawv ntawm cov pab pawg neeg sib txawv, kev nce ntxiv hauv cov kab ke ntawm rosuvastatin ntawm cov neeg Nyij Pooj thiab Suav tau sau tseg. Qhov tseeb no yuav tsum raug coj los txiav txim siab thaum sau ntawv rau rosuvastatin rau cov pab pawg neeg mob no. Kev siv cov tshuaj hauv ib koob ntawm 40 mg yog contraindicated hauv cov neeg mob ntawm haiv neeg Mooboid.
Cov neeg mob raum tsis ua haujlwm
Hauv cov neeg mob uas mob mentsis lossis mob raum tsis ua haujlwm, koob tshuaj yuav tsis tas kho. Kev siv tag nrho cov tshuaj ntawm cov tshuaj Akorta yog contraindicated rau hauv cov neeg mob uas mob raum tsis ua haujlwm (creatinine tshem tawm tsawg dua 30 ml / min).
Kev siv cov tshuaj hauv qhov ntau npaum ntawm 40 mg yog contraindicated nyob rau hauv cov neeg mob uas muaj mob me hauv lub raum tsis ua haujlwm (creatinine tshem tawm tsawg dua 60 ml / min).
Cov neeg mob mob siab tsis ua haujlwm
Tsis muaj kev paub dhau los ntawm kev siv cov tshuaj hauv cov neeg mob uas tau tus qhab nia saum toj 9 ntawm Childe-Pugh nplai. Qhov tshuaj Akorta yog sib kis rau cov neeg mob uas muaj kab mob hauv lub siab (nrog rau kev nce ntxiv hauv kev ua haujlwm ntawm "daim siab" hloov mus rau lub siab, nrog rau kev nce ntxiv hauv kev ua haujlwm ntawm "daim siab" hloov mus rau hauv cov ntshav cov ntshav ntau dua 3 zaug piv nrog kev txwv qis ntawm ib txwm muaj).