Cov tshuaj Glidiab MV: cov lus qhia rau kev siv, tshuaj xyuas

Gliclazide yog qhov ncauj tshuaj hypoglycemic hais txog tshuaj ntsuab rau lub zog sulfonylureas 2nd tiam. Qhov kev txiav txim ntawm cov tshuaj yog qhia rau kev ua kom muaj β-hlwb hauv txiavtsim khoom tshuaj insulin, ntau dua kev raug mob ntawm cov ntaub so ntswg txuas ntxiv rau nws, nce ntxiv piam thaj insulin secretion teebmeem thiab txhawb kev ua haujlwm ntawm intracellular glycogen synthetase hauv cov leeg ua ke. Cov tshuaj txo cov sijhawm hauv lub sijhawm txij li lub sijhawm ua zaub mov mus txog thaum pib ntau lawm tshuaj insulintxo qis postprandial qabzib, thiab tseem rov kho qhov ntxov (thawj) ncov cov tshuaj insulin zais cia (tsis zoo li lwm yam tshuaj sulfonylureasfeem ntau ua haujlwm nyob rau theem ob).

Ntxiv nrog rau kev tswj kev ua kom muaj roj metabolism gliclazide txhim kho microcirculationlos ntawm kev txo qis platelet aggregation thiab kev nplaum, normalization ntawm vascular permeability, kho tshiab ntawm cov txheej txheem physiological parietal fibrinolysis.

Glidiab kev kho mob txo cov kev mob vascular adrenalinetiv thaiv kev tsim atherosclerosis thiab microthrombosisCov. Txwv tsis pub muaj kev loj hlob ntawm cov tsis tshaj tawm (tom qab) uas yog kuaj ntshav qab zibCov. Nrog rau kev kho mob ntev, muaj qhov txo qis pom tshuaj proteinuriatab tom xyaum keeb kwm yav dhau losuas mob ntshav qab zib nephropathy.

Noj tshuaj, vim nws cov nyhuv rau theem thaum ntxov insulin zais cia, tsis yog nrog los ntawm kev nce phaus thiab tseem nyiam nws txo qis hauv cov neeg mob rog, yog tias tsim nyog kev kho kev noj haus.

Qhov ncauj tswj hwm gliclazide ua rau nws txoj kev nqus yuav luag tiav hauv cov hnyuv. TCmax hauv ntshiab ntshav 4 teev (rau cov ntsiav tshuaj MV - 6-12 teev). Kev khi rau cov ntshav plasma protein yog nyob rau theem ntawm 90-95%. Kev hloov pauv khoom noj muaj tshwm sim hauv lub siab nrog kev tso tawm ntawm cov khoom tsis tawm metabolism hauvCov. T1 / 2 yog 8-11 teev (rau MV cov ntsiav tshuaj - 16 teev). Daim Ntawv Tsis Txaus Siab metabolites nqa tawm feem ntau los ntawm lub raum (li 70%), nrog rau txoj hnyuv (12%). Li ntawm 1% gliclazide tawm tsis hloov pauv hauv zis.

Kev ntsuas rau siv

Glidiab yog qhia rau ntshav qab zib hom 2 (NIDDM, tsis muaj ntshav qab zib-insulin-tiv thaiv ntshav qab zib) nrog tib txhij kev kho kev noj haus thiab tuakev siv lub cev muaj teeb meem nyuaj yog tias lawv tsis muaj txiaj ntsig yav dhau los.

Kev siv cov Glidiab yog contraindicated nyob rau hauv:

• mob ketoacidosis,
• pub niam mis,
• ntshav qab zib hom 1,
• uas precom /coma,
• mob siab hnyav pathologies/raum,
• hyperosmolar coma,
• leukopenia,
• mob mob, nrog qhov xav tau siv tshuaj insulinsuav nrog kev raug mob, phais kev ua haujlwmdav hlawv,
• paresis ntawm lub plab,
• ntawm cev xeeb tub,
• hnyuv tawm tsam,
• pathologies nrog los ntawm malabsorption cov khoom noj thiab cov duab ntshav qog (suav nrog cov mob sib kis)
• tus kheej kev tiv thaiv tsis haum rau gliclazide lossis lwm yam tshuaj
• thaum yau.

Sab sij huam

Qhov feem ntau muaj thiab mob tshwm sim ntawm Glidiab yog ntshav qog, feem ntau tshwm sim los ntawm kev ua txhaum ntawm kev haus tshuaj thiab tsis txaus kev kho kev noj hausCov. Cov tsos mob ntawm qhov kev cuam tshuam no yog ntau haiv neeg thiab tuaj yeem tshwm sim nws tus kheej: mob taub haukev tshaib kev nqhis zoo nkaus li nkeesdheev tsis muaj zoginattention ntxhov siab, txhoj puab heevtxob taus nyuaj siab lub xeevqeeb cov tshuaj tiv thaiv, tsis muaj peev xwm mloog zoo, pom kev pomtsis paub pab aphasiapiav thoob hlo tshee hnyo, kiv taub hau, delirium, kev plam tus kheej, spasmstsis nco qab hypersomniapa ua tsis taus pa hws, bradycardia.

Qhov thib ob tseem ceeb tshaj plaws corking los ntawm Glidiab txoj kev kho yog suav tias yog qhov tsis zoo pom los ntawm kev mob plab, uas tau hais tawm dyspepsia (xeev siabepigastric heev thiab zawv plab), kev ua txhaum hepatic muaj nuj nqi (nce hauv kev ua sidaim siab ua kua transaminase, cholestatic mob daj ntseg), kev tsis nco qab (siv tshuaj ntsiav nrog zaub mov, mob heev kev tsis nco qab txo qis).

Tej zaum tseem yuav tsim kev tsis haummas sawv hauv urticaria, maculopapular pob thiab khaus tawv.

Qee zaum pom tsim leukopenia, thrombocytopenia thiab anemia.

Glidiab, cov lus qhia rau kev siv

Qhov kev xaiv ntawm cov tshuaj ntau npaum li cas ntawm cov tshuaj Glidiab yog nqa tawm ib leeg zuj zus raws li kev kuaj mob NIDDM thiab qib txhauv, uas yog ntsuas ntawm lub plab khoob, tas li tom qab 2 teev tom qab noj mov.

Thaum pib, kom noj tshuaj txhua hnub ntawm 1 Glidiab 80 mg ntsiav tshuaj lossis koob thib 1 Glidiab MV 30 mg ntsiav tshuaj tau pom zoo. Qhov nruab nrab txhua hnub muab tshuaj yog 160 mg thiab 60 mg, thiab qhov siab tshaj plaws yog 320 mg thiab 120 mg, feem, rau cov tshuaj thiab MV ntsiav tshuaj. Conventional Glidiab 80 mg ntsiav tshuaj yog noj 30-60 feeb ua ntej noj mov ob zaug hauv 24 teev (thaum sawv ntxov thiab yav tsaus ntuj). Ntsiav tshuaj MV 30 mg yog qhia tias yuav tsum noj ib zaug sawv ntxov thaum noj tshais. Kev txhaj tshuaj ntau ntxiv tuaj yeem nqa nrog ib ncua sijhawm tsawg kawg 14 hnub.

Cov laus thiab cov neeg mob nrog pathologies ntawm ob lub raum (nrog CC 15-80 ml / min) tsis xav tau hloov qhov tshuaj.

Noj ntau dhau

Nyob rau hauv cov ntaub ntawv ntawm overdose gliclazide tau pom txoj kev loj hlob ntshav qogqee zaum ncav cuaghypoglycemic coma.

Thaum muaj tsos mob ntawm kev haus ntau dhau ua rau tus neeg mob nco qab, nws yuav tsum haus tam sim ntawd qab zib tov lossis piam thaj (dextrose) Hauv kev tsis nco qab ntawm tus neeg mob, cov tshuaj tov dej yog qhia Dextrose (40%) lossis IM kev txhaj tshuaj Glucagon (1-2 mg). Yav tom ntej, nrog qee qhov kev hloov kho kom zoo, tus neeg mob yuav tsum noj zaub mov nrog cov muaj cov ntsiab lus siab carbohydrates, rau lub hom phiaj ceeb toom Rov qab huam yuaj ntawm hypoglycemia.

Kev sib txuam

Kev txo qis hauv hypoglycemic zoo ntawm Glidiab yog pom nyob rau hauv cov ntaub ntawv ntawm nws thaum uas tig mus siv nrog glucocorticoids, barbituratessympathomimetics (Terbutaline, Epinephrine, Ritodrin, Clonidine, Salbutamol), calcium antagonists, ntsev ntsev, nicotinic acid, thiazide diureticscarbonic anhydrase inhibitors (Diacarb), Chlortalidone, Triamteren, Chlorpromazine, Furosemide, Asparaginase, Danazol, Baclofen, Diazoxide, Rifampicin, Morphine, Isoniazid, Glucagon, Phenytoin, cov tshuaj hormones lub qog thiab tshuaj estrogen (suav nrog tshuaj tiv thaiv qhov ncauj).

Ib qho kev nce hauv hypoglycemic kev ua si ntawm Glidiab tau sau tseg nrog nws siv ua ke nrog cov tshuaj tua kabmob (Fluconazole, Miconazole), ACE inhibitors (Enalapril, Captopril), H2-blockers (Cimetidine), fibrates (Bezafibrat, Clofibrate), NSAIDs (Indomethacin, Phenylbutazone, Diclofenac), salicylates, anti-TB tshuaj (Kev Ncaj Ncees), cov tsis tuaj leej twg tog, β-blockersanabolic tshuaj yuam CyclophosphamideMAO inhibitors Chloramphenicol, Theophylline, Allopurinolsulfonamides ntev heev, Fenfluramine, Pentoxifylline, Fluoxetine, Guanethidine, Reserpine, tubular secretion blockers, Disopyramide, Bromocriptine, Pyridoxine, ethanol, thiab nrog rau lwm cov tshuaj hypoglycemic (tshuaj insulin, lojmuas, acarbose).

Kev sib koom tes ntawm Glidiab thiab mob glycosides nce txoj kev pheej hmoo ntawm kev tsim ventricular extrasystole.

Qhov cuam tshuam ntawm β-blockers Reserpine, Clonidine, Guanethidine tej zaum yuav ua rau pom mob dab tsi ntshav qog.

Cov lus qhia tshwj xeeb

Kev kho tus mob Glidiab yuav tsum tau txais kev txhawb nqakev noj zaub mov kom tsis muaj calorie tsawgnrog tsawg tsawg ua ke carbohydrates.

Kev tsis haum xeeb nyob rau hauv cov zaub mov noj, nrog rau kev ntxhov siab thiab lub cev lub zog xav tau kev kho kom haum ntau npaum gliclazide.

Thoob plaws hauv chav kawm ntawm txoj kev kho, nws yog ib qho tsim nyog yuav tau soj ntsuam glycemia qibXyuas nws ntawm lub plab khoob thiab tom qab noj mov.

Ntawm decompensation mob ntshav qab zibli qub kev pab cuam phais mob siv tau yuav tsum txiav txim siab cov tshuaj insulin npaj.

Yuav tsum qhia rau tus neeg mob txog qhov tsim tau ntshav qog thaum yoo mov, noj NSAIDs thiab ethanol-muaj npaj.

Qhov tshwj xeeb tshaj yog nkag siab txog qhov tshwm sim ntawm cov tshuaj hypoglycemic yog cov neeg laus, cov neeg mob uas tsis muaj zog, lossis cov neeg uas tsis tau txais kev noj zaub mov zoo, thiab tib neeg kev txom nyem kev siab phem.

Kev ceev faj yuav tsum tau siv thaum ua qhov haujlwm txaus ntshai lossis meej ua haujlwm, nrog rau kev tsav tsheb, tshwj xeeb tshaj yog thaum xaiv cov tshuaj ntau npaum li cas, vim qhov kev pheej hmoo ntawm tsim muaj ntshav qog.

• Glemaz,
• Amaril,
• Lus hauv no teb Khoom,
• Amix,
• Glibetic,
• Diabrex,
• Glianov,
• Maninil,
• Glibenclamide,
• Diameprid,
• Glimepiride,
• Diapiride,
• Glinova,
• Meglimide,
• Glurenorm,
• Thaj neeb,
• Eglim lwm yam.

• Glidia MV,
• Lawj Xeeb MR,
• Gliklada,
• Khaws,
• Gliclazide MR,
• Kev kuaj mob MR,
• Gluktam,
• Diabinax,
• Glucostabil,
• Diatics,
• Lub Neej,
• Diabresid,
• Osiklid.

Cov kev paub dhau los ntawm kev kho mob Glidiab hauv cov neeg mob hauv cov menyuam hnub nyoog muaj hnub nyoog txaus yuav tsis tau txais sijhawm rau nws kev teem caij rau menyuam yaus.

Nrog cawv

Yog tias koj haus cawv thaum noj cov tshuaj Glidiab, koj yuav ntsib kevdisulfiram-zoo li cov tshuaj tiv thaiv (mob) manifesting mob plab, xeev siab/ntuav, mob taub hau.

Thaum cev xeeb tub thiab lactation

Siv nyob rau hauv kev kho mob ntawm Glidiab nrog pub niam mis thiab ntawm cev xeeb tub txwv tsis pub.

Glidiab txheeb xyuas nyob hauv net yog ob peb, tab sis qhov zoo dhau heev. Raws li cov neeg mob tau txais nws, cov tshuaj daws tau nrog cov kev pom tsis zoo. mob ntshav qab zib tsis yog insulin thiab muaj qhov tsawg kawg ntawm kev phiv. Lawm, thaum noj Glidiab, koj yuav tsum tswj hwm qhov tsim nyog kev noj haus thiab ua raws li cov lus pom zoo rau kev siv lub cev.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Daim ntawv qhia cov tshuaj rau tso tawm ntawm Glidiab MV yog ntsiav tshuaj nrog kev hloov pauv hloov: tiaj-cylindrical, dawb nrog cream zas lossis dawb, beveled, marbling yog lees paub (10 daim hauv hlwv, hauv pob ntawv los ntawm 3 lossis 6 pob).

Composition 1 ntsiav tshuaj:

• cov tshuaj nquag: gliclazide - 30 mg,
• Cov khoom pabcuam: microcrystalline cellulose - 123 mg, hypromellose - 44 mg, magnesium stearate - 2 mg, colloidal silicon dioxide - 1 mg.

Cov Tshuaj Pharmacokinetics

Gliclazide tom qab kev tswj hwm ntawm qhov ncauj yog yuav luag nqus ntawm lub plab zom mov. Nws lub plasma concentration nce qeeb zuj zus thiab nce mus txog qhov siab kawg nkaus hauv 6-12 teev. Noj mov tsis cuam tshuam rau kev nqus ntawm qhov khoom ntawd.

Nrog rau ib koob tshuaj Glidiab MV txhua hnub, ib qho kev kho kab mob ntshav ntshav zoo ntawm gliclazide tau muab rau 24 teev.

Plasma protein khi yog kwv yees li 95%.

Kev mob plab zom mov tshwm sim hauv daim siab nrog rau kev tsim cov tshuaj tom qab thaum lub cev tsis ua haujlwm.

T_1/2 (ib nrab-lub neej) yog kwv yees li 16 teev. Nws yog tawm hauv feem ntau los ntawm lub raum hauv daim ntawv ntawm cov tshuaj metabolites, kwv yees li 1% ntawm cov tshuaj tau tawm tsis pauv hauv cov zis.

Cov Yuav Tsum Tau Ua

• ntshav qab zib hom 1
• mob ketoacidosis,
• mob ntshav qab zib coma / precoma,
• tej yam kev mob uas nrog malabsorption ntawm cov zaub mov, qhov tshwm sim ntawm hypoglycemia (kis mob),
• hyperosmolar coma,
• paresis ntawm lub plab
• leukopenia
• mob hnyav / mob raum tsis zoo,
• hnyuv ob tog,
• muaj kev phais ntau, kev raug mob dav, kub hnyiab thiab lwm yam mob uas yuav tsum tau kho tshuaj insulin,
• kev sib txuas ua ke nrog miconazole, danazole lossis phenylbutazone,
• hnub nyoog txog 18 xyoo
• cev xeeb tub thiab lactation,
• tus kheej tsis haum rau ib qho twg ntawm cov tshuaj, nrog rau sulfonamides thiab lwm yam sulfonylureas.

Tus txheeb ze (Glidiab MV yog tshuaj raws li kev saib xyuas mob):

• febrile mob
• quav cawv
• noj tsis txaus / tsis xwm yeem,
• tsis txaus / adrenal tsis txaus,
• cov kab mob hnyav heev ntawm cov kab mob plawv (suav nrog atherosclerosis, mob plawv)
• raum / nplooj siab tsis ua haujlwm,
• Kev Ua Siab Ncaj
• piam thaj-6-phosphate dehydrogenase tsis txaus,
• Lub caij nyoog ntev siv ntawm glucocorticosteroids,
• mob qog, ua raws kev ua txhaum ntawm nws txoj haujlwm,
• hnub nyoog siab heev.

Cov lus qhia rau kev siv Glidiab MV: txoj kev thiab qhov tshuaj

Glidiab MV noj ntawm qhov ncauj, 1 ib hnub nyob rau ib hnub thaum noj tshais.

Cov koob tshuaj ntawm cov tshuaj yog xaiv los ntawm tus kws kho mob ib leeg zuj zus raws li kev soj ntsuam cov tsos mob ntawm tus kabmob, yoo cov kua nplaum thiab 2 teev tom qab noj mov.

Thawj qhov tshuaj thawj hnub yog 1 ntsiav tshuaj. Hauv lub neej yav tom ntej, yog tias tsim nyog, nce qhov koob tshuaj nrog ib ncua nrog tsawg kawg 2 lub lis piam. Qhov siab tshaj plaws yog 4 ntsiav tshuaj hauv ib hnub.

Nws tuaj yeem hloov pauv ntawm Glidiab mus rau Glidiab MV hauv ib koob li 1-4 ntsiav tshuaj txhua hnub.

Kev kho tuaj yeem ua ke nrog lwm cov kab mob hypoglycemic: biguanides, insulin lossis alpha-glucosidase inhibitors.

Yeeb tshuaj sib cuam tshuam

Kev sib xyaw ua ke uas cov ntshav qabzib tuaj yeem nce (txo cov nyhuv ntawm gliclazide):

• danazol: kev sib xyaw tsis pom zoo, cov tshuaj muaj cov mob ntshav qab zib, yog tias nws tsis tuaj yeem hloov nws nrog lwm cov tshuaj, qhov siab ntawm cov piam thaj hauv cov ntshav yuav tsum tau saib xyuas, qhov tshuaj ntawm Glidiab MV tuaj yeem hloov kho los ntawm tus kws kho mob thaum ua ke nrog kev kho mob thiab tom qab ua tiav,
• chlorpromazine (hauv koob tshuaj 100 mg txhua hnub): kev sib xyaw ua ke yuav tsum tau ceev faj, vim tias muaj kev nce siab ntau ntxiv ntawm cov piam thaj hauv cov ntshav thiab txo qis ntawm cov tshuaj insulin, yog tias tsis tuaj yeem hloov nws nrog lwm cov tshuaj, qhov siab ntawm cov piam thaj hauv cov ntshav yuav tsum tau saib xyuas, thaum lub sijhawm sib koom ua ke thiab tom qab ua tiav, tus kws kho mob yuav kho koob tshuaj Glidiab MV,
• tetracosactide thiab glucocorticosteroids (kev siv hauv zos / kev siv: kev siv tshuaj, qhov quav thiab lub chaw tswj hwm sab nraud): kev sib koom ua ke yuav tsum ceeb toom, vim tias muaj kev nce ntshav hauv cov ntshav nrog kev txhim kho ntawm ketoacidosis, nws tau pom zoo kom ua tib zoo saib xyuas ntshav qabzib hauv siab, tshwj xeeb tshaj yog thaum pib kho, thaum ua ke kev kho mob thiab tom qab nws ua tiav los ntawm tus kws kho mob, qhov tshuaj ntawm Glidiab MV tuaj yeem hloov kho,
• salbutamol, ritodrin, terbutaline (kev tswj hwm kom zoo): kev sib xyaw ua ke yuav tsum ceev faj,
• anticoagulants (tshwj xeeb yog cov tshuaj warfarin): cov tshuaj tiv thaiv anticoagulants ntau ntxiv (tej zaum yuav tau kho kom haum).

Kev sib txuas ua ke uas qhov kev pheej hmoo ntawm kev txhim kho hypoglycemia nce (nce kev ua ntawm gliclazide):

• miconazole (cov txheej txheem ntawm cov txheej txheem lossis ib qho tshuaj pleev rau hauv daim ntawv ntawm gel rau ntawm qhov hnoos qeev ntawm lub qhov ncauj ntawm qhov ncauj): kev sib txuam yog contraindicated, txij li thaum hypoglycemia tuaj yeem tsim kho kom txog thaum tsis nco qab,
• phenylbutazone (kev tswj hwm kev tswj hwm): kev sib xyaw ua ke tsis pom zoo, yog tias tsis tuaj yeem hloov nws nrog lwm cov tshuaj, qhov siab ntawm cov piam thaj hauv cov ntshav yuav tsum tau saib xyuas, qhov tshuaj ntawm Glidiab MV tuaj yeem hloov kho los ntawm tus kws kho mob thaum lub sijhawm sib koom ua ke thiab tom qab ua tiav,
• ethanol: kev sib xyaw ua ke tsis pom zoo, uas cuam tshuam nrog nce ntawm hypoglycemia thiab qhov ntxim nyiam ntawm kev txhim kho hypoglycemic coma,
• lwm cov kab mob hypoglycemic (insulin, alpha-glucosidase inhibitors, metformin, thiazolidinediones, dipeptidyl peptidase-4 inhibitors, glucagon-zoo li peptide-1 agonists), tsis siv tshuaj tiv thaiv tsis haum tshuaj, fluconazole, beta-adrenergic blockers, neurotransmitter antagonists,₂- histamine receptors, monoamine oxidase inhibitors, clarithromycin, sulfonamides: kev sib txuam yuav tsum ceeb toom.

Cov lus piv txwv ntawm Glidiab MV yog: Diabeton MB, Diabefarm MV, Gliclazide Canon, Glidiab, Gliclada, Diabetalong, Diabinax, Diabefarm.

Tus yam ntxwv dav

Cov tshuaj "Glidiab MV 30" yog suav tias yog tshuaj Lavxias analogue ntawm Fabkis txoj tshuaj "Ntshav qab zib MV". Nws yog tsim los ntawm Akrikhin Tshuaj thiab Chaw Cog Khoom hauv cheeb tsam Moscow.

Cov tshuaj yog hais txog qhov ncauj qhov ncauj ntshav lub cev nyob hauv cov ntsiav tshuaj daim ntawv muaj qhov hloov kho tawm. Cov xim ntawm lawv cov qauv yog dawb los yog qab zib, tej zaum yuav yog pob ua ntoo. Cov ntsiav tshuaj zoo li lub tiaj tus.

Cov neeg siv khoom ntim yog pob. Nws yuav ntim li 30 lossis 60 ntsiav tshuaj, ntim hauv hlwv hlwv.

Tsis zoo li cov tshuaj "Diabeton MV" nrog ib koob tshuaj 0,060 g ntawm gliclazide, cov tshuaj "Glidiab MV" muaj ib qho muaj cov khoom siv zoo tib yam ob zaug qis dua, uas yog 0.030 g.

Cov tshuaj tsis ua hauj lwm muaj xws li hydroxypropylmethyl cellulose, aerosilic lwg me me, magnesium stearate, microcrystalline cellulose.

Kuj tseem muaj cov tshuaj "Glidiab" nrog kev tso tawm ib txwm ntawm cov tshuaj nquag. Qhov ntau npaum li cas hauv ib ntsiav tshuaj yog 0.08 g ntawm gliclazide.

Nws yuav ua haujlwm li cas

Cov lus qhia rau kev siv txuas nrog rau Glidiab MV tshuaj noj piav txog cov txiaj ntsig ntawm glyclazide, uas ua rau cov tshuaj insulin tso rau hauv cells-cov hlwb uas nyob hauv cov txiav ua qab.

Hauv qab ntawm cov ntsiav tshuaj, insulin secretory kev ua haujlwm ntawm cov kua nplaum ntev ntxiv, thiab cov ntaub so ntswg feem ntau ua rau cov tshuaj insulin tsis txaus siab.

Nqaij glycogen synthetase, yog nyob rau hauv qhov ua rau enzyme, zoo dua. Muaj qhov txo qis hauv lub sij hawm txij li thaum pib noj mov mus rau tso tawm qhov hormone. Cov tshuaj insulin tso rov qab los ntawm qhov pib thaum ntxov, uas paub qhov txawv ntawm gliclazide los ntawm lwm yam sulfonylurea ua ntej, qhov kev nqis tes ua uas tshwm sim hauv theem ob. Theem postprandial piam thaj txo.

Muaj kev txhim kho microcirculation vim yog kev sib koom ua ke thiab kev txhawm rau cov platelet, ua haujlwm tsis tu ncua ntawm permeability ntawm cov vascular phab ntsa, qhov txo qis hauv kev txhim kho microthrombotic thiab atherosclerosis cov txheej txheem, thiab kho kom rov qab los ntawm cov kev hloov pauv ntawm ntuj tso tseg ntawm cov ntshav txhaws. Tseem muaj qhov tshwm sim ntawm receptor formations hauv cov hlab ntsha mus rau adrenaline lwg me me.

Cov tshuaj muaj peev xwm maj mam txo cov ntshav qab zib kom zoo ntawm kev rov ua haujlwm ntawm qhov tsis nyob ntawm theem. Kev kho mob ntev ntev nrog cov tshuaj no nyob rau hauv cov ntshav qab zib ua rau kev puas tsuaj rau lub Cheebtsam lub raum lub luag haujlwm rau kev limtiam tuaj yeem txo qis kev cuam tshuam ntawm cov protein nyob hauv cov zis.

Cov tshuaj tsis ua kom qhov hnyav ntawm lub cev, tab sis, theej nws vim tias muaj kev cuam tshuam rau thaum ntxov ntawm insulin secretion. Nws tsis ua rau mob insulin nce ntau ntxiv.

Nws siv rau dab tsi?

Cov kws kho mob pom zoo kom siv cov tshuaj nrog cov ntshav qab zib ntawm lub degree ob. Kev kho mob yog nqa tawm nrog lub txiaj ntsig tsis txaus ntawm kev noj haus thiab mob lub cev ib ce dhau mus.

Txog rau Glidiab MV noj tshuaj, qhov ntsuas pom tau cuam tshuam nrog kev tiv thaiv kev ploj hauv cov kab mob ntshav qab zib, yam ntxwv tsis xws li nephropathy, retinopathy, myocardial infarction thiab mob stroke.

Yuav siv li cas

Qhov ntau npaum ntawm cov tshuaj yog xaiv rau txhua tus neeg mob cais, noj mus rau hauv tus account qhov tshwm sim ntawm tus kab mob, qabzib concentration nrog ib npliag plab thiab 120 feeb tom qab noj mov.

Txog cov tshuaj "Glidiab MV", cov lus qhia rau kev siv tshuaj los kho ib hnub pib ntawm 0.03 g, uas yog sib npaug rau ib ntsiav tshuaj. Qhov kev xav no yog qhia rau cov neeg laus laus tom qab 65 xyoo. Cov tshuaj yog siv qhov ncauj noj ib ntsiav tshuaj thaum sawv ntxov thaum noj tshais.

Yog tias tsim nyog, ntau npaum li cas tau ntxiv txhua ob lub lis piam. Qhov siab tshaj ntawm ib hnub raug tso cai siv kwv yees li 0.120 g, uas sib haum rau 4 ntsiav tshuaj.

Cov tshuaj "Glidiab MV" yog siv hloov cov tshuaj ntawm tib lub npe nrog cov niaj zaus tso tawm, noj 1-4 ntsiav tshuaj ib hnub.

Nws ua ke nrog tus neeg sawv cev hypoglycemic raws li biguanide, ib qho alpha-glucosidase inhibitor ntawm cov tshuaj insulin.

Thaum lub cev tsis ua haujlwm lub plawv los ntawm lub cev tsis muaj zog lossis lub cev qhov hnyav, thaum tus nqi ntawm kev tsim tawm tsis ntau tshaj 0.080 litres ib feeb, qhov tshuaj tsis txo.

Thaum twg tsis xav coj

Glidiab MV cov ntsiav tshuaj tsis pom zoo siv rau thawj hom mob ntshav qab zib mellitus, nrog kev nce hauv ketones hauv cov zis, nrog mob plab paresis, nrog hyperosmolar, mob ntshav qab zib tsis nco qab thiab precoma, nrog kev phais loj thiab hlawv cov kev raug mob, mob tshwm sim thaum muaj insulin xav tau kev kho mob.

Cov txheej txheem tiv thaiv yog kev ua txhaum loj ntawm hepatic lossis lub raum ua haujlwm, mob plab hnyuv, hloov pauv ntawm kev nqus khoom noj, kev txhim kho hauv lub xeev hypoglycemic.

Koj tuaj yeem siv tsis tau cov tshuaj rau kub taub hau, mob leukopenia, cev xeeb tub, pub niam mis thiab haus cawv ntau dhau rau hauv cov tshuaj ntawm cov tshuaj.

Ceev faj yog qhov yuav tsum tau ua thaum tswj kev noj tshuaj, kev saib xyuas tshwj xeeb thiab kev xaiv cov tshuaj rau cov neeg mob uas quav cawv thiab tsis cuam tshuam cov thyroid caj pas.

Cov yam ntxwv khomob

Txog cov tshuaj "Glidiab MV", cov lus qhia rau kev siv qhia tias yuav tsum tau muab nws sib xyaw nrog kev noj zaub mov kom tsawg, nrog rau cov ntsiab lus tsawg carbohydrate. Kev soj ntsuam tas li ntawm cov concentration ntawm cov piam thaj hauv cov ntshav txij thaum sawv ntxov ua ntej thiab tom qab noj mov yuav tsum tau.

Yog tias muaj kev ua haujlwm phais lossis decompensation ntawm tus mob ntshav qab zib, qhov kev qhia ntawm cov tshuaj insulin yog ua tau.

Muaj cov lus ceeb toom txog kev tshwm sim ntawm cov txheej txheem hypoglycemic nrog kev siv cov dej cawv ethyl, tsis muaj tshuaj tiv thaiv tsis haum thiab tsis muaj zaub mov noj. Kev haus dej haus cawv tuaj yeem ua rau disulfiram-zoo li mob syndrome, thaum lub taub hau thiab lub plab mob, xeev siab thiab ntuav yog tau.

Qhov ntau ntawm cov tshuaj yuav tsum tau kho thaum lub cev lossis kev ntxhov siab ntxhov siab thiab nrog kev noj zaub mov kom tsis txaus.
Tshwj xeeb tshaj yog rhiab rau cov nyhuv ntawm cov tshuaj yog cov neeg laus, cov neeg mob tsis txaus noj haus lossis kev noj zaub mov tsis zoo, cov neeg mob tsis muaj zog uas raug kev tiv thaiv tsis txaus ntawm adrenal-pituitary.

Thaum pib thawj theem ntawm kev siv tshuaj thaum xaiv tshuaj, yog tias muaj lub siab xav mus rau qhov teebmeem kev kub ntxhov, koj tsis tas yuav ua yeeb yam uas xav tau kev nce siab ntxiv thiab cov tshuaj tiv thaiv psychomotor ceev.

Kev phiv tshuaj

Rau Glidiab MV, kev qhia muaj xws li cov lus qhia txog kev txawv txav hauv endocrine plab hnyuv siab thaum lub sijhawm ua haujlwm tsis zoo hauv kev tswj hwm ntawm kev siv ntsiav tshuaj thiab thaum noj zaub mov tsis zoo. Feem ntau, cov ntshav qabzib tsawg nyob rau hauv cov hlab ntshav ua rau muaj mob taub hau, nkees, tshaib plab, tsis paub pab, txhawj xeeb txog qhov zoo, tam sim ntawd tsis muaj zog, ua rau muaj kev kub ntxhov, ua rau lub siab poob qis, thiab lub xeev muaj kev nyuaj siab. Tsis tas li, muaj kev hloov pauv ntawm qhov pom ntawm lub qhov muag, tshee tshee, hnov ​​qhov muag thiab pom qhov txawv txav, kiv taub hau, hypersomnia, ua pa nyuaj, thiab lub plawv dhia.

Lub plab zom mov plab tsis ua haujlwm nyob rau hauv daim ntawv ntawm malabsorption, xeev siab, raws plab, tsis muaj qhov ua kom tsis qab los, ua haujlwm ntawm lub siab ua haujlwm, cholestatic jaundice, thiab nce ntxiv ntawm cov txiaj ntsig ntawm transaminase enzymes.

Cov txheej txheem tsis txaus siab nyob hauv cov kab mob hematopoietic yog txuam nrog kev txo qis ntawm hemoglobin, platelet thiab leukocyte suav.

Cov tshuaj yuav ua rau muaj kev tsis haum tshuaj nyob rau hauv daim ntawv ntawm khaus, urticaria, maculopapular pob.

Kev qhia ntau dhau

Cov lus qhia rau kev siv txuas nrog rau Glidiab MV kev ceeb toom tawm tsam kev tshaj tawm, uas yog qhia los ntawm qhov txo qis cov piam thaj hauv cov ntshav ntshav. Nrog rau qhov muaj zog dhau ntawm cov tshuaj, kev txhim kho ntawm lub qog ntshav qab zib tsis zoo yog ua tau.

Txhawm rau tshem tawm nws, ib tus neeg raug tso cai noj qee yam zoo-hydrocarbons, piv txwv li, ib qho qab zib. Thaum tus neeg tsis nco qab lawm, 40% dextrose lossis kua nplaum tov rau hauv cov leeg ntshav, thiab glucagon tau txhaj rau hauv cov leeg hauv qhov nyiaj ntawm 1 mg. Yog hais tias tus neeg mob tsim thaum sawv, ces nws raug yuam kom noj zoo-hydrocarbons kom tsis txhob rov ua dua ntawm qhov kev ua tsis zoo rau qhov mob ntshav qab zib.

Ua ke nrog tshuaj

Lub hypoglycemic ua si ntawm lub medicament "Glidiab CF 30 mg" yuav kho kom zoo los ntawm qhia thaum uas tig mus angiotensin converting enzyme inhibitor thiab Monoamine oxidase hom receptor blocker formations beta adrenozavisimyh thiab H2 gistaminozavisimyh raws li cimetidine, thiab flukonazolovyh mikonazolovyh noj tshuaj, uas tsis yog-tshuaj anti-inflammatory cov neeg ua hauj phenylbutazone, indomethacin, diclofenac.

Cov nyhuv ntawm cov ntsiav tshuaj yog txhim kho nrog clofibrates thiab bezafibrates, tshuaj tiv thaiv TB los ntawm cov pab pawg ntawm ethionamide, salicylates, indirect anticoagulant tebchaw ntawm cov qauv coumarin, anabolic steroids, cyclophosphamides, chloramphenicol, sulfonamides nrog cov nyhuv ntev.

Cov tshuaj muaj txiaj ntsig zoo dua txo cov ntshav qab zib thaum siv tubular blockers, ethyl cawv, acarbose, biguanide, insulin.

Txo cov nyhuv hypoglycemic ntawm cov ntsiav tshuaj yog tshwm sim los ntawm barbiturates, tshuaj raws li epinephrine, clonidine, terbutaline, rhytodrin, salbutamol, kuj yog phenytoin, inhibitors ntawm carbonic anhydrase enzyme xws li acetazolamide, thiazide diuretics, cov tshuaj hormones ntawm cov tshuaj thyroid gland, lithium-uas muaj tshuaj.

Molecules ntawm ethyl cawv muaj peev xwm ua tau ntawm gliclazide nrog qhov tshwm sim ntawm disulfiram zoo li cov txheej txheem.

Cov nquag ua haujlwm ntawm cov ntsiav tshuaj ua rau tsis txaus ntseeg siab tsis pom kev tsis haum thiab txhaws ntawm lub ventricles ntawm myocardial leeg thaum ua ke nrog mob glycosides.

Beta-blockers, clonidine, reserpine, guanethidine tshuaj npog cov tshuaj tiv thaiv ntshav qog ntshav qab zib.

Tus neeg mob lub tswv yim

Qhov tseem ceeb tsis yog tsuas yog cov lus qhia rau kev siv txuas rau Glidiab MV tshuaj noj. Cov lus tshuaj xyuas tham txog seb cov neeg mob xav li cas txog kev ua tau zoo ntawm cov tshuaj. Cov cuab yeej no pab ntau tus neeg mob txo cov ntshav qabzib mus rau qhov tseem ceeb, thiab ua ke nrog cov khoom noj muaj txiaj ntsig hloov pauv tus neeg mob lub neej.

Cov neeg nco ntsoov tias qhov zoo ntawm cov ntsiav tshuaj yog lawv qhov yooj yim siv thaum sawv ntxov. Thaum nruab hnub, koj tsis tuaj yeem nco txog qhov xav tau kev kho mob.

Ntawm cov tshuaj "Glidiab MV" kev tshuaj xyuas tuaj yeem hnov ​​thiab tsis zoo, muaj feem nrog qhov tsis muaj txiaj ntsig ntawm cov cuab yeej no. Qhov no feem ntau tshwm sim thaum txoj kev noj tshuaj tsis yog, thaum me me ntawm cov tshuaj tau hais tseg.

Kev Sib Sau thiab daim ntawv ntawm kev tso tawm

• Nquag: 0.03 g ntawm gliclazide
• Tus pab: hypromellose, MCC, aerosil, E572.

Ntsiav tshuaj nyob rau hauv daim ntawv ntawm ib lub tiaj tus kheej kheej nrog beveled sawv, dawb los yog creamy. Kev tsim nyog marbling ntawm tus qauv tsis yog ntxeev. Ntim hauv 10 daim nyob rau hauv blisters. Hauv ntim cov duab los qhia - 3 lossis 6 contour paib, neeg siv phau ntawv.

Kho thaj chaw

Ib cov tshuaj nrog cov nyhuv hypoglycemic raws li glycazide, ib qho kev sib txuas ntawm lub cim thib ob ntawm sulfonylurea. Nws pab txhawb tsim cov tshuaj insulin hauv lub cev, txhim kho cov ntaub so ntswg mus rau insulin thiab insulin-secretory nyhuv ntawm cov piam thaj. Rov kho lub qub ncov ntawm insulin secretion, txhim kho microcirculation, txo platelet sib sau ua ke, rov kho qhov tsim nyog vascular permeability.

Kev noj cov tshuaj tsis cuam tshuam rau kev sau cov phaus ntxiv, vim tias nws feem ntau cuam tshuam rau kev tsim ntawm lub ncov thaum ntxov hauv insulin secretion.

Txoj kev ntawm daim ntawv thov

Cov tshuaj yog tsim tshwj rau kev kho neeg laus. Glidiab MV ntsiav tshuaj, raws li cov lus qhia rau kev siv, coj ib hnub ib zaug, zoo tshaj thaum sawv ntxov nrog zaub mov. Cov tshuaj yog nqos tau tag nrho, tsis tuaj yeem raug tom los yog ntuag.

Yog tias vim qee qhov kev txais tos tsis tuaj lawm, tom qab ntawd rov qab ntxiv qhov omission nrog ob zaug koob tsis pom zoo. Tsis nco qab haus tshuaj yuav tsum quag cawv tom qab thaum sawv ntxov. Qhov ntau npaum ntawm cov tshuaj, zoo ib yam li cov tshuaj hypoglycemic, ib txwm xaiv ib tus zuj zus rau txhua tus neeg mob raws li nws cov lus pov thawj ntawm ntshav qabzib thiab hemoglobin qib.

Qhov pom zoo kom muab thawj zaug yog 30 mg rau ib hnub. Tom qab ntawd, nws tuaj yeem hloov kho mus rau 60, 90 thiab 120 mg. Nws raug tso cai los nce cov kev cai niaj hnub ntawm cov tshuaj tsuas yog ib hlis tom qab txhaj thawj zaug. Muaj kev zam tshwj xeeb yog kev mob thaum pib kho tsis tau ua tiav qhov kev cia siab, thiab cov piam thaj tseem nyob rau tib theem (ua ntej txoj kev kho). Hauv cov xwm txheej no, qhov ntau npaum li cas tuaj yeem tau nce ntxov - tom qab 14 hnub.

HF nrog kev kho tu yog 30-120 mg.

Yog tias nws yog qhov yuav tsum tau hloov tus neeg mob nrog Glidiab 80 mg rau cov tshuaj uas muaj lub sijhawm ntev (MV 30 mg), nws yog nqa tawm tom qab kuaj xyuas cov piam thaj hauv ib qho kev sib piv ntawm 1: 1. Yog tias tus neeg mob yav dhau los coj lwm cov tshuaj hypoglycemic, tom qab ntawd hloov chaw yuav tsum ua nrog qhov muab xam ntawm cov tshuaj dhau los HF thiab lub sijhawm nws tshem tawm. Tsis tas yuav soj ntsuam lub sijhawm hloov, thawj zaug SN ntawm Glidiab MV yog 30 mg, tom qab ntawd nws tuaj yeem hloov tau.

Yog tias tus neeg mob tau noj cov tshuaj nrog lub sij hawm ntev ntawm kev ua kom zoo los ntawm cov tshuaj nquag, so ib pliag yuav tsum tau tiv thaiv kom tsis txhob ntxiv cov nyhuv ntxiv. Tom qab qhov no, koj tuaj yeem pib noj tshuaj ncua sijhawm ntev nrog kev siv tshuaj txhua hnub ntawm 30 mg.

Dosage kev kho kom haum los ntawm lub hnub nyoog rau cov neeg laus laus (65+) tsis tas yuav. Rau cov tib neeg muaj kev pheej hmoo, 30 mg ntawm CH yog kho.

Hauv kev tiv thaiv ntawm kev mob ntshav qab zib, kev noj tshuaj txhua hnub tuaj yeem raug nce rau qhov siab tshaj plaws ntawm 120 mg los ua qhov ntsuas ntxiv rau kev noj zaub mov zoo thiab ua kom lub cev. Kev txais tos yog ua tiav kom txog rau thaum cov ntsuas ntsuas ib txwm ua, coj mus rau hauv qhov kev pheej hmoo ntawm kev mob ntshav qab zib.

Hauv kev cev xeeb tub, HB

Nws yog qhov tsis tsim nyog rau cov poj niam siv cov tshuaj qhov ncauj uas txo cov ntshav qabzib thaum lub sijhawm yug menyuam, vim tias tsis muaj pov thawj kev nyab xeeb ntawm Glidiab MV.

Hauv kev npaj rau cev xeeb tub lossis thaum nws tshwm sim tawm tsam tom qab ntawm chav kawm ntawm Glidiab MV ntsiav tshuaj, cov tshuaj yuav tsum tau muab tshem tawm thiab tus poj niam yuav tsum tau kho cov tshuaj insulin.

Tsis muaj ib qho ntaub ntawv txaus ntseeg ntawm seb cov tshuaj tawm mus rau niam mis yog li cas, yog li ntawd, nws tsis tshua xav muab cov tshuaj hypoglycemic nrog lactation. Thaum lub sijhawm noj HB ntsiav tshuaj, nws yuav tsum raug muab tso tseg kom tsis txhob ua rau cov ntshav qabzib hauv cov menyuam yaus tsawg dua.

Hla kev sib txuam yeeb tshuaj

Thaum lub sijhawm kho nrog Glidiab MV ntsiav tshuaj, lub peev xwm ntawm gliclazide muaj kev cuam tshuam nrog cov tshuaj ntawm lwm cov tshuaj yuav tsum raug coj los ua.Qhov phom sij tshwj xeeb tshaj yog tuaj yeem ua ke nrog cov tshuaj uas txhim kho cov nyhuv ntawm gliclazide, txij li qhov kev hem thawj ntawm hypoglycemic coma tau nce ntau.

Nws yog nruj me ntsis txwv tsis pub coj los ua ke ntawm Glidiab MV kho nrog Miconazole (cov kab ke hauv lub cev lossis sab nraud hauv daim ntawv ntawm lub ntsej muag), vim tias qhov no ua rau mob tsis nco qab, uas tuaj yeem ua rau tuag taus.

Nws tsis pom zoo kom muab cov tshuaj nrog phenylbutazone rau tib qho laj thawj. Nws yuav tsum tau hloov nrog lwm cov tshuaj tiv thaiv. Yog tias nws tsis tuaj yeem thim nws, tus neeg mob yuav tsum paub txog cov kev pheej hmoo txaus ntshai thiab qhov xav tau kom tas li saib xyuas cov piam thaj hauv cov ntshav.

Nws yog txwv tsis pub coj los ua ke nrog cov cawv uas muaj cawv los yog tshuaj, txij li cov dej cawv txhawb txoj kev txhim kho hypoglycemic coma.

Muaj ntau tus lej tshuaj uas tuaj yeem ua nrog ceev faj nrog Glidiab MV. Cov tshuaj no suav nrog insulin, metformin, alpha-glucoside inhibitors, beta-blockers, sulfonamides, NSAIDs, thiab lwm yam Yog tias tsim nyog, lawv siv yuav tsum ua tib zoo saib rau cov tsos mob uas tsis xav tau.

Danazol ua rau cov ntshav qab zib ua kom tsis muaj zog, ua kom lub zog ntawm gliklidiza thiab pab ua kom cov ntshav qabzib ntau hauv cov ntshav. Yog tias nws tsis tuaj yeem hloov cov tshuaj nrog lwm cov tshuaj, tus neeg mob yuav tsum saib xyuas cov ntshav qab zib tas li, yog tias tsim nyog, qhov ntau npaum ntawm Glidiab MV yuav tsum tau kho.

Chlorpromazine tsub kom cov ntshav qabzib ntau thiab tsawg cov tshuaj insulin. Kev tswj cov piam thaj hauv ntshav qab zib tas li yog qhov tsim nyog, kev txiav txim siab ceev faj qhov ntau ntawm cov tshuaj gliclazide nrog kev siv ua ke ntawm Glidiab MV thaum kho nrog Chlorpromazine thiab tom qab nws tshem tawm.

Tshuaj nrog corticosteroids nrog rau txhua txoj kev ntawm kev thov (sab nraud, hauv zos, pob ntseg lossis qhov quav) nce siab ntxiv thiab pab ua rau muaj kev tshwm sim ntawm ketoacidosis. Thaum ua ke nrog hom tshuaj no, kev saib xyuas cov ntshav qab zib tas li yog ua tiav thiab nws yog qhov yuav tsum tau ua tib zoo txiav txim siab kev nyab xeeb tshaj plaws ob leeg thaum tib lub sijhawm kawm thiab tom qab kawg ntawm kev kho tshuaj hormones.

Nrog rau cov chav kawm sib txuas nrog cov tshuaj tiv thaiv (anticoagulants), nws muaj peev xwm txhim kho lawv cov kev ua. Yuav tau ua kom haum.

Sab sij huam

Noj Glidiab MV ntsiav tshuaj tej zaum yuav yog nrog lub cev tsis haum lub cev.

Zoo li txhua yam tshuaj ntawm sulfonylurea pab pawg, cov tshuaj tuaj yeem ua rau mob ntshav qab zib yog tias cov ntsiav tshuaj noj tsis xwm yeem thiab tshwj xeeb tshaj yog noj zaub mov hla. Nyob rau hauv xws li mob, tus mob yog nrog nrog:

• Mob taub Hau
• Kev tshaib plab heev
• Xeev siab, ntuav ntuav
• Nkees
• Tus pw tsis tsaug zog los yog nkees nkees
• Kev khaus pim heev
• Kev poob siab
• Kev tiv thaiv ntawm kev tsis haum tshuaj
• Qhov tab kaum
• Nyuaj siab
• Kev ntxhov siab ntawm kev nco qab, hais lus thiab pom kev
• Kiv taub hau
• Cramps
• Ua pa
• Ncuav Qab Zib
• Thaum muaj mob hnyav, ua rau tsis nco qab nrog txoj kev tsis nco qab lossis tuag yog ua tau.

Tsis tas li, tus neeg mob tuaj yeem ntsib lwm yam kev cuam tshuam:

• Muaj hws ntau
• Daim tawv nqaij nplaum
• Kev loj hlob BP
• Tachycardia
• Arrhythmia
• Angina pectoris.

Lwm cov xwm txheej, kev noj cov ntsiav tshuaj tuaj yeem nrog cov kev cuam tshuam ntawm qee qhov kabmob:

• Lub plab zom mov: xeev siab, txhaws ntuav, mob plab, raws plab lossis quav tawv. Txhawm rau zam qhov mob uas tsis xav tau lossis txo qis kev siv, cov ntsiav tshuaj tau pom zoo kom noj nrog zaub mov.
• Daim tawv nqaij: ua pob, khaus, Quincke's edema, erythema, kev ua xua.
• Hematopoietic plab hnyuv siab raum: anemia, leukopenia, thrombocytopenia. Cov xwm txheej yog ib ntus: lawv dhau los ntawm lawv tus kheej tom qab tshem tawm cov tshuaj.
• Nplooj Siab: ua kom cov enzymes, muaj tsawg - kab mob siab. Yog tias muaj cov tsos mob ntawm tus mob cholestatic daj ntseg, tom qab ntawv kho yuav tsum tau muab tshem tawm.
• Organs ntawm lub zeem muag: txo qis hauv qhov pom tseeb (feem ntau tshwm sim thaum pib ntawm qhov pib vim muaj kev hloov pauv hauv cov piam thaj).

Lwm cov kev mob tshwm sim uas yog cov yam ntxwv ntawm sulfonylurea kev npaj muaj:

• Erythropenia
• Mob Kev Plab
• Vasculitis
• Kev Hyponatremia
• Agranulocytosis.

Cov lus thiab cov xwm txheej ntawm kev cia

Glidiab yog lub tshuaj xaj tau tshuaj.

Khaws cov ntsiav tshuaj hauv qhov chaw qhuav, nkag tsis tau rau ya raws thiab tshav ntuj, ntawm qhov kub txog li 25 ºС. Raws li cov xwm txheej no, lub neej ua haujlwm ntawm Glidiab yog 4 xyoos, thiab Glidiab MV yog 2 xyoos.

Pom qhov yuam kev hauv cov ntawv nyeem? Xaiv nws thiab nias Ctrl + Enter.

Lub hauv paus ntsiab lus ntawm cov tshuaj

Cov tshuaj rau kev kho mob "qab zib" ntawm hom thib ob yog muaj nyob hauv ntsiav tshuaj daim ntawv, cov tshuaj tseem ceeb ntawm cov tshuaj yog glyclazide. Cov tshuaj ntawm cov ntsiav tshuaj suav nrog cov khoom siv ntxiv - microcrystalline cellulose, magnesium stearate thiab lwm yam tshuaj.

Cov lus luv "MV", muaj nyob rau hauv lub npe tshuaj, sawv cev rau kev hloov kho tawm. Kev tshuaj xyuas ntawm tus kws kho mob tau lees tias qhov nuance no tso cai rau koj yuav tsum noj cov tshuaj ib hnub ib zaug.

Cov khoom tseem ceeb thaum lub sij hawm nqus tau pab txhawb qhov kev ua ntawm cov leeg glycogen synthetase thiab kev tsim tawm ntawm cov tshuaj insulin hauv lub cev. Tsis tas li ntawd, cov ntsiab lus tseem ceeb txiav txim siab txog insulin secretory kev txiav txim siab ntawm qab zib, uas ua rau muaj kev cuam tshuam ntau ntxiv rau nws ntawm qib ntawm tes.

Ntawm qhov tsis muaj qhov tseem ceeb yog qhov tseeb tias Glidiab ntsiav tshuaj pab txo lub sij hawm nruab nrab ntawm kev siv khoom noj thiab pib ua haujlwm nquag ntawm insulin. Ceeb toom rau txoj kev hais daws tau qhia tias kev siv cov tshuaj txo qis ntawm qhov siab ntawm lub xeev hyperglycemic, thaum muaj kev rov ua dua ntawm kev ua tiav thaum ntxov ntawm kev ua yeeb yam.

Tag nrho cov yam ntxwv saum toj no muaj qhov cuam tshuam ncaj qha rau kev zom cov zaub mov carbohydrate thiab microcirculation. Kev siv cov tshuaj Glidiab txo qis kev pheej hmoo ntawm kev txhim kho atherosclerotic hloov pauv ntawm cov hlab ntsha.

Vim tias qhov peculiarities ntawm daim ntawv noj tshuaj, ib koob tshuaj ib hnub tau lees tias ib qho kev kho mob zoo ntawm cov tshuaj nquag nyob hauv ntshav rau 24 teev.

Cov lus qhia rau kev siv ntsiav tshuaj

Qhov kev daws teeb meem ntawm cov tshuaj Glidiab MB qhia tau hais tias cov tshuaj tau pom zoo rau kev kho mob ntshav qab zib mellitus hauv kev sib xyaw nrog kev noj zaub mov kom tsawg thiab ua kom lub cev zoo.

Raws li txoj cai, cov tshuaj ib txwm ua yog cov txhais tau tias tsuas txo qis ntshav qab zib. Tsuas yog hauv qee kis tshwj xeeb nws tuaj yeem pom zoo hauv kev kho mob kis tau tus kab mob. Piv txwv, hauv kev sib xyaw nrog kev npaj los ntawm cov pab pawg biguanide.

Qhov ntau npaum ntawm cov tshuaj yog tshuaj raws li ntsuas ntawm qab zib cov ntsiab lus ntawm ib plab khoob, nrog rau ob teev tom qab noj mov.

Ntawm Glidiab, cov lus qhia rau kev siv muab cov ncauj lus nram qab no:

1. Cov ntsiav tshuaj raug pom zoo kom noj ib hnub ib zaug, lub sijhawm noj su yog sawv ntxov ua ntej noj mov.
2. Qhov nruab nrab, cov tshuaj rau ib hnub yog 80 mg, suav nrog rau cov neeg mob laus (tshaj 65).
3. Yog hais tias kho qhov ua tau zoo tsis txaus, nws raug tso cai kom maj mam nce cov tshuaj nrog rau ib ncua sijhawm ntawm 14 hnub.
4. Qhov ntau kawg noj rau ib hnub tsis ntau tshaj 320 mg.

Yog tias tus neeg mob tau ua rau lub siab thiab lub raum tsis ua haujlwm, ces yuav tsum tau txhaj koob tshuaj ntawm Glidiab MV tsis tas yuav.

Tus nqi ntawm cov tshuaj, qhov ntim ntawm cov tshuaj yog 80 mg (60 ntsiav tshuaj ib pob) yog 134 rubles. Tus nqi ntawm 60 ntsiav tshuaj hauv qhov tshuaj ntawm 30 mg yog 130 rubles. Glidiab MB yog me ntsis kim kim, tus nqi yog rau 60 pcs. 80 mg txhua yog 185 rubles.

Analogues ntawm cov tshuaj

Hauv ntau qhov xwm txheej, Glidiab tsis pom zoo kom sau ntawv vim tias muaj qhov sib txuam ntawm qhov sib txuam, qhov kev pheej hmoo siab ntawm cov kev mob tshwm sim los ntawm lub hauv nruab nrab ntawm cov hlab ntsha thiab cov hlab plawv.

Hauv qhov no, cov tshuaj zoo sib xws. Cov tshuaj noj rau Glidiab yog: Formin, Amaryl, Diabrex, Maninil, Glurenorm thiab lwm yam tshuaj rau kev kho mob ntshav qab zib.

Hloov cov tshuaj nrog rau ib los yog lwm cov tshuaj yuav tsum tau nqa tawm tshwj xeeb los ntawm tus kws kho mob mus koom, tsis muaj dab tsi ntxiv.

Cia peb xav txog cov analogues hauv kev nthuav dav ntxiv:

• Formmetin yog cov tshuaj uas pom zoo rau kev kho mob ntshav qab zib hom 2 thaum kev noj zaub mov ua kom tsis muaj txiaj ntsig. Nws feem ntau pom zoo ua ke nrog cov tshuaj uas yog sulfonylurea derivatives.
• Maninil ntsiav tshuaj muaj lub ntsiab nquag muaj tshuaj glibenclamide, yog sulfonylurea derivatives. Cov tshuaj txhawb cov nquag tsim tawm ntawm cov tshuaj insulin, muab cov insulin-excreting effect ntawm cov piam thaj.
• Glibenclamide yog tshuaj rau tus mob ntshav qab zib zaum ob, thaum nws tsis tuaj yeem them nyiaj rau cov kab mob pathology los ntawm kev noj haus thiab kis las. Qhov ntau npaum li cas yog tshuaj raws li cov piam thaj ntsuas, nws tuaj yeem sib txawv ntawm 2.5 txog 15 mg. Tshaj tawm ntawm kev siv ntau zaus hauv ib hnub.
• Amaryl - ib tus neeg sawv cev hypoglycemic, yog raug kho rau kev kho mob ntawm hom thib ob ntawm kev kho mob tsuas yog siv tshuaj los yog muaj kev sib xyaw nrog insulin lossis metformin. Raws li txoj cai, kev kho mob nrog cov tshuaj no yog nqa tawm rau lub sijhawm ntev.

Cov tshuaj Glidiab thiab nws cov analogues ua tau zoo ntawm kev kho "kab mob". Txawm li cas los xij, nrog rau cov khoom muaj txiaj ntsig zoo, lawv muaj contraindications thiab phiv. Yog li, kev teem caij yuav tsum ua los ntawm tus kws kho mob nkaus xwb.

Kev noj tshuaj pab ua rau lub cev txo cov ntshav qabzib ntau thiab ruaj khov rau ntawm qib uas xav tau. Tab sis, txhawm rau txhawm rau txhim kho txoj kev ua tau zoo ntawm kev siv tshuaj, tus neeg mob yuav tsum ua raws li kev noj haus thiab kev tawm dag zog kom nce qhov rhiab ntawm cov nqaij mos kom ua kom qabzib.

Koj xav li cas txog qhov no? Koj tus kws kho mob muab tshuaj dab tsi rau koj noj, thiab koj tuaj yeem qhia nws dab tsi los ntawm qhov pom ntawm koj tus kheej qhov kev paub dhau los?